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Target
Casein kinase II subunit alpha
Ligand
BDBM50140975
Substrate
n/a
Meas. Tech.
ChEMBL_1548867 (CHEMBL3755571)
Ki
2490±n/a nM
Citation
 Lukowska-Chojnacka, E; Winska, P; Wielechowska, M; Poprzeczko, M; Bretner, M Synthesis of novel polybrominated benzimidazole derivatives-potential CK2 inhibitors with anticancer and proapoptotic activity. Bioorg Med Chem 24:735-41 (2016) [PubMed]  Article 
Target
Name:
Casein kinase II subunit alpha
Synonyms:
CK II | CK2 | CK2- alpha | CK2A1 | CSK21_HUMAN | CSNK2A1 | Casein kinase 2 | Casein kinase II (CK2) | Casein kinase II alpha/beta | Casein kinase II subunit alpha (CK2 alpha) | Casein kinase II subunit alpha (CK2A1) | Casein kinase II subunit alpha (CK2a I174A) | Casein kinase II subunit alpha (CK2a V66A) | Casein kinase II subunit alpha (CK2a dm V66I174AA) | Casein kinase II subunit alpha (CK2a)
Type:
Enzyme
Mol. Mass.:
45151.12
Organism:
Homo sapiens (Human)
Description:
P68400
Residue:
391
Sequence:
MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ
  
Inhibitor
Name:
BDBM50140975
Synonyms:
CHEMBL3751963
Type:
Small organic molecule
Emp. Form.:
C11H7Br4N3
Mol. Mass.:
500.809
SMILES:
Brc1c(Br)c(Br)c2n(CCCC#N)cnc2c1Br
Structure:
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