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Target
REST corepressor 1 [4-485]
Ligand
BDBM50155769
Substrate
n/a
Meas. Tech.
ChEMBL_1564915 (CHEMBL3782872)
IC50
61±n/a nM
Citation
 Vianello, P; Botrugno, OA; Cappa, A; Dal Zuffo, R; Dessanti, P; Mai, A; Marrocco, B; Mattevi, A; Meroni, G; Minucci, S; Stazi, G; Thaler, F; Trifiró, P; Valente, S; Villa, M; Varasi, M; Mercurio, C Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent. J Med Chem 59:1501-17 (2016) [PubMed]  Article 
Target
Name:
REST corepressor 1 [4-485]
Synonyms:
KIAA0071 | Protein CoREST | RCOR | RCOR1 | RCOR1_HUMAN | REST corepressor 1
Type:
PROTEIN
Mol. Mass.:
53029.95
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108118
Residue:
482
Sequence:
MVEKGPEVSGKRRGRNNAAASASAAAASAAASAACASPAATAASGAAASSASAAAASAAAAPNNGQNKSLAAAAPNGNSSSNSWEEGSSGSSSDEEHGGGGMRVGPQYQAVVPDFDPAKLARRSQERDNLGMLVWSPNQNLSEAKLDEYIAIAKEKHGYNMEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKTFHRIQQMLPDKSIASLVKFYYSWKKTRTKTSVMDRHARKQKREREESEDELEEANGNNPIDIEVDQNKESKKEVPPTETVPQVKKEKHSTQAKNRAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKRQIQNIKQTNSALKEKLDGGIEPYRLPEVIQKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVNYRRRFNIDEVLQEWEAEHGKEETNGPSNQKPVKSPDNSIKMPEEEDEAPVLDVRYASAS
  
Inhibitor
Name:
BDBM50155769
Synonyms:
CHEMBL3780542
Type:
Small organic molecule
Emp. Form.:
C28H31ClN4O4
Mol. Mass.:
523.023
SMILES:
Cl.N[C@@H]1C[C@H]1c1ccc(NC(=O)c2ccc(N3CCOCC3)c(NC(=O)OCc3ccccc3)c2)cc1 |r|
Structure:
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