Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase 17B
Ligand
BDBM50304112
Substrate
n/a
Meas. Tech.
ChEMBL_1575376 (CHEMBL3802094)
IC50
250±n/a nM
Citation
 Jung, ME; Byun, BJ; Kim, HM; Lee, JY; Park, JH; Lee, N; Son, YH; Choi, SU; Yang, KM; Kim, SJ; Lee, K; Kim, YC; Choi, G Discovery of indirubin derivatives as new class of DRAK2 inhibitors from high throughput screening. Bioorg Med Chem Lett 26:2719-23 (2016) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase 17B
Synonyms:
DRAK2 | ST17B_HUMAN | STK17B | Serine/threonine-protein kinase 17B | Serine/threonine-protein kinase 17B (STK17B)
Type:
Enzyme
Mol. Mass.:
42332.49
Organism:
Homo sapiens (Human)
Description:
O94768
Residue:
372
Sequence:
MSRRRFDCRSISGLLTTTPQIPIKMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWDFENLFHPEETSSSSQTQDHSVRSSEDKTSKSSCNGTCGDREDKENIPEDSSMVSKRFRFDDSLPNPHELVSDLLC
  
Inhibitor
Name:
BDBM50304112
Synonyms:
(Z)-5'-Amino-1H,1'H-[2,3']biindolylidene-3,2'-dione 3-oxime | 5'-Amino-1H,1'H-[2,3']biindolylidene-3,2'-dione 3-oxime | CHEMBL604263
Type:
Small organic molecule
Emp. Form.:
C16H12N4O2
Mol. Mass.:
292.2921
SMILES:
Nc1ccc2NC(=O)C(c2c1)c1[nH]c2ccccc2c1N=O
Structure:
Search PDB for entries with ligand similarity: