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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM50107009
Substrate
n/a
Meas. Tech.
ChEMBL_1581027 (CHEMBL3813032)
IC50
28000±n/a nM
Citation
 Schroeder, RL; Goyal, N; Bratton, M; Townley, I; Pham, NA; Tram, P; Stone, T; Geathers, J; Nguyen, K; Sridhar, J Identification of quinones as novel PIM1 kinase inhibitors. Bioorg Med Chem Lett 26:3187-91 (2016) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM50107009
Synonyms:
5-Hydroxy-7-methyl-[1,4]naphthoquinone | 5-hydroxy-7-methyl-1,4-naphthoquinone | 7-methyljuglone | CHEMBL430853
Type:
Small organic molecule
Emp. Form.:
C11H8O3
Mol. Mass.:
188.1794
SMILES:
Cc1cc(O)c2C(=O)C=CC(=O)c2c1 |c:8|
Structure:
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