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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM50174539
Substrate
n/a
Meas. Tech.
ChEMBL_1581027 (CHEMBL3813032)
IC50
19200±n/a nM
Citation
 Schroeder, RL; Goyal, N; Bratton, M; Townley, I; Pham, NA; Tram, P; Stone, T; Geathers, J; Nguyen, K; Sridhar, J Identification of quinones as novel PIM1 kinase inhibitors. Bioorg Med Chem Lett 26:3187-91 (2016) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM50174539
Synonyms:
CHEMBL1987813
Type:
Small organic molecule
Emp. Form.:
C14H12O7
Mol. Mass.:
292.2409
SMILES:
O[C@H]1CC2=C([C@@H](O)[C@H]1O)C(=O)c1c(O)ccc(O)c1C2=O |c:3|
Structure:
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