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Target
14-3-3 protein eta
Ligand
BDBM50177028
Substrate
n/a
Meas. Tech.
ChEMBL_1582332 (CHEMBL3816075)
Kd
70.0±n/a nM
Citation
 Watanabe, N; Osada, H Small molecules that target phosphorylation dependent protein-protein interaction. Bioorg Med Chem 24:3246-54 (2016) [PubMed]  Article 
Target
Name:
14-3-3 protein eta
Synonyms:
14-3-3 protein eta | 1433F_HUMAN | Protein AS1 | YWHA1 | YWHAH
Type:
PROTEIN
Mol. Mass.:
28205.81
Organism:
Homo sapiens (Human)
Description:
ChEMBL_110546
Residue:
246
Sequence:
MGDREQLLQRARLAEQAERYDDMASAMKAVTELNEPLSNEDRNLLSVAYKNVVGARRSSWRVISSIEQKTMADGNEKKLEKVKAYREKIEKELETVCNDVLSLLDKFLIKNCNDFQYESKVFYLKMKGDYYRYLAEVASGEKKNSVVEASEAAYKEAFEISKEQMQPTHPIRLGLALNFSVFYYEIQNAPEQACLLAKQAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDEEAGEGN
  
Inhibitor
Name:
BDBM50177028
Synonyms:
CHEMBL3814675
Type:
Small organic molecule
Emp. Form.:
C101H157N27O29S3
Mol. Mass.:
2309.686
SMILES:
CSCC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCCN1)C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(O)=O |r|
Structure:
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