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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50186347
Substrate
n/a
Meas. Tech.
ChEMBL_1587590 (CHEMBL3825575)
EC50
14±n/a nM
Citation
 Matsuda, D; Kobashi, Y; Mikami, A; Kawamura, M; Shiozawa, F; Kawabe, K; Hamada, M; Oda, K; Nishimoto, S; Kimura, K; Miyoshi, M; Takayama, N; Kakinuma, H; Ohtake, N Design and synthesis of 1H-pyrazolo[3,4-c]pyridine derivatives as a novel structural class of potent GPR119 agonists. Bioorg Med Chem Lett 26:3441-6 (2016) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50186347
Synonyms:
CHEMBL3824111
Type:
Small organic molecule
Emp. Form.:
C25H29F2N5O3
Mol. Mass.:
485.5263
SMILES:
CCCNC(=O)c1cc(F)c(cc1F)-c1cc2cnn(C3CCN(CC3)C(=O)OC(C)C)c2cn1
Structure:
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