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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50186719
Substrate
n/a
Meas. Tech.
ChEMBL_1587590 (CHEMBL3825575)
EC50
177±n/a nM
Citation
 Matsuda, D; Kobashi, Y; Mikami, A; Kawamura, M; Shiozawa, F; Kawabe, K; Hamada, M; Oda, K; Nishimoto, S; Kimura, K; Miyoshi, M; Takayama, N; Kakinuma, H; Ohtake, N Design and synthesis of 1H-pyrazolo[3,4-c]pyridine derivatives as a novel structural class of potent GPR119 agonists. Bioorg Med Chem Lett 26:3441-6 (2016) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50186719
Synonyms:
CHEMBL3822545
Type:
Small organic molecule
Emp. Form.:
C22H26N4O5S
Mol. Mass.:
458.531
SMILES:
CC(C)OC(=O)N1CCC(CC1)n1ncc2cc(Oc3ccc(cc3)S(C)(=O)=O)ncc12
Structure:
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