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Target
Outer membrane protein MIP
Ligand
BDBM50200295
Substrate
n/a
Meas. Tech.
ChEMBL_1622004 (CHEMBL3864356)
IC50
21400±n/a nM
Citation
 Seufert, F; Kuhn, M; Hein, M; Weiwad, M; Vivoli, M; Norville, IH; Sarkar-Tyson, M; Marshall, LE; Schweimer, K; Bruhn, H; Rösch, P; Harmer, NJ; Sotriffer, CA; Holzgrabe, U Development, synthesis and structure-activity-relationships of inhibitors of the macrophage infectivity potentiator (Mip) proteins of Legionella pneumophila and Burkholderia pseudomallei. Bioorg Med Chem 24:5134-5147 (2016) [PubMed]  Article 
Target
Name:
Outer membrane protein MIP
Synonyms:
MIP_LEGPN | Macrophage infectivity potentiator | PPIase | Peptidyl-prolyl cis-trans isomerase | Rotamase | mip
Type:
PROTEIN
Mol. Mass.:
24869.94
Organism:
Legionella pneumophila
Description:
ChEMBL_701873
Residue:
233
Sequence:
MKMKLVTAAVMGLAMSTAMAATDATSLATDKDKLSYSIGADLGKNFKNQGIDVNPEAMAKGMQDAMSGAQLALTEQQMKDVLNKFQKDLMAKRTAEFNKKADENKVKGEAFLTENKNKPGVVVLPSGLQYKVINAGNGVKPGKSDTVTVEYTGRLIDGTVFDSTEKTGKPATFQVSQVIPGWTEALQLMPAGSTWEIYVPSGLAYGPRSVGGPIGPNETLIFKIHLISVKKSS
  
Inhibitor
Name:
BDBM50200295
Synonyms:
CHEMBL3963890
Type:
Small organic molecule
Emp. Form.:
C21H27N3O4S
Mol. Mass.:
417.522
SMILES:
Nc1ccc(CS(=O)(=O)N2CCCCC2C(=O)OCCCc2cccnc2)cc1
Structure:
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