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Target
Sphingomyelin phosphodiesterase 2
Ligand
BDBM50221661
Substrate
n/a
Meas. Tech.
ChEMBL_144779 (CHEMBL751444)
IC50
114000±n/a nM
Citation
 Hamada, M; Iikubo, K; Ishikawa, Y; Ikeda, A; Umezawa, K; Nishiyama, S Biological activities of alpha-mangostin derivatives against acidic sphingomyelinase. Bioorg Med Chem Lett 13:3151-3 (2003) [PubMed]  Article 
Target
Name:
Sphingomyelin phosphodiesterase 2
Synonyms:
Lyso-PAF-PLC | Lyso-platelet-activating factor-phospholipase C | N-SMase | NSMA_HUMAN | Neutral sphingomyelinase | SMPD2 | Sphingomyelin phosphodiesterase 2 | nSMase
Type:
PROTEIN
Mol. Mass.:
47650.63
Organism:
Homo sapiens (Human)
Description:
ChEMBL_144777
Residue:
423
Sequence:
MKPNFSLRLRIFNLNCWGIPYLSKHRADRMRRLGDFLNQESFDLALLEEVWSEQDFQYLRQKLSPTYPAAHHFRSGIIGSGLCVFSKHPIQELTQHIYTLNGYPYMIHHGDWFSGKAVGLLVLHLSGMVLNAYVTHLHAEYNRQKDIYLAHRVAQAWELAQFIHHTSKKADVVLLCGDLNMHPEDLGCCLLKEWTGLHDAYLETRDFKGSEEGNTMVPKNCYVSQQELKPFPFGVRIDYVLYKAVSGFYISCKSFETTTGFDPHRGTPLSDHEALMATLFVRHSPPQQNPSSTHGPAERSPLMCVLKEAWTELGLGMAQARWWATFASYVIGLGLLLLALLCVLAAGGGAGEAAILLWTPSVGLVLWAGAFYLFHVQEVNGLYRAQAELQHVLGRAREAQDLGPEPQPALLLGQQEGDRTKEQ
  
Inhibitor
Name:
BDBM50221661
Synonyms:
CHEMBL110445
Type:
Small organic molecule
Emp. Form.:
C24H28O7
Mol. Mass.:
428.4749
SMILES:
[#6]-[#8]-c1c(-[#8])cc(-[#8])c(-[#6](=O)-c2c(-[#8])cc(-[#8])c(-[#6]\[#6]=[#6](/[#6])-[#6])c2-[#8])c1-[#6]\[#6]=[#6](/[#6])-[#6]
Structure:
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