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Target
Sodium- and chloride-dependent betaine transporter
Ligand
BDBM50226144
Substrate
n/a
Meas. Tech.
ChEMBL_202581 (CHEMBL806331)
IC50
2000±n/a nM
Citation
 Brehm, L; Krogsgaard-Larsen, P; Schaumburg, K; Johansen, JS; Falch, E; Curtis, DR Glycine antagonists. Synthesis, structure, and biological effects of some bicyclic 5-isoxazolol zwitterions. J Med Chem 29:224-9 (1986) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent betaine transporter
Synonyms:
Na(+)/Cl(-) betaine/GABA transporter | S6A12_RAT | Slc6a12 | Sodium- and chloride-dependent betaine transporter | Solute carrier family 6 member 12
Type:
PROTEIN
Mol. Mass.:
69749.57
Organism:
Rattus norvegicus
Description:
ChEMBL_105007
Residue:
614
Sequence:
MDRKVTVHEDGCPVVSWVPEEGEMMDQKDKDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFSCGIPVFFLEVALGQYSSQGSVTAWRKICPLLQGIGMASVVIESYLNIYYIIILAWALFYLFSSFTWELPWTTCTNSWNTEHCVDFLNYSSTRAASYSENFTSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLIILLIRGVTLPGAYQGIVFYLKPDLLRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYRDSIALCFLNSATSFVAGFVVFSILGFMAQEQGVPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLFFLMLLFLGLDSQFVCMECLVTASMDMFPQQLRKRGRRELLILAVAIVCYLMGLLLVTEGGMYIFQLFDYYASSGICLLFLSLFEVICIGWVYGADRFYDNVEDMIGYRPWPLVKISWLFLTPGLCLATFFFSLSKYTPLKYNNVYIYPSWGYSIGWLLAFSSMACVPLFIIITLLKTQGSFKKRLQRLITPDPSLPQPGRRSPQDGSSAQNCSTSPVKQELIAWEKETHL
  
Inhibitor
Name:
BDBM50226144
Synonyms:
2,4-Diamino-Butyric Acid | CHEBI:64307 | CHEMBL307931 | DL-2,4-diaminobutyric acid
Type:
Small organic molecule
Emp. Form.:
C4H10N2O2
Mol. Mass.:
118.1344
SMILES:
NCCC(N)C(O)=O
Structure:
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