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Target
Sialic acid-binding Ig-like lectin 7
Ligand
BDBM50230649
Substrate
n/a
Meas. Tech.
ChEMBL_1644943 (CHEMBL3993872)
IC50
25600000±n/a nM
Citation
 Prescher, H; Frank, M; Gütgemann, S; Kuhfeldt, E; Schweizer, A; Nitschke, L; Watzl, C; Brossmer, R Design, Synthesis, and Biological Evaluation of Small, High-Affinity Siglec-7 Ligands: Toward Novel Inhibitors of Cancer Immune Evasion. J Med Chem 60:941-956 (2017) [PubMed]  Article 
Target
Name:
Sialic acid-binding Ig-like lectin 7
Synonyms:
AIRM-1 | AIRM1 | Adhesion inhibitory receptor molecule 1 | CD_antigen=CD328 | CDw328 | D-siglec | QA79 membrane protein | SIGL7_HUMAN | SIGLEC7 | Sialic acid-binding Ig-like lectin 7 | Siglec-7 | p75
Type:
PROTEIN
Mol. Mass.:
51147.68
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109858
Residue:
467
Sequence:
MLLLLLLPLLWGRERVEGQKSNRKDYSLTMQSSVTVQEGMCVHVRCSFSYPVDSQTDSDPVHGYWFRAGNDISWKAPVATNNPAWAVQEETRDRFHLLGDPQTKNCTLSIRDARMSDAGRYFFRMEKGNIKWNYKYDQLSVNVTALTHRPNILIPGTLESGCFQNLTCSVPWACEQGTPPMISWMGTSVSPLHPSTTRSSVLTLIPQPQHHGTSLTCQVTLPGAGVTTNRTIQLNVSYPPQNLTVTVFQGEGTASTALGNSSSLSVLEGQSLRLVCAVDSNPPARLSWTWRSLTLYPSQPSNPLVLELQVHLGDEGEFTCRAQNSLGSQHVSLNLSLQQEYTGKMRPVSGVLLGAVGGAGATALVFLSFCVIFIVVRSCRKKSARPAADVGDIGMKDANTIRGSASQGNLTESWADDNPRHHGLAAHSSGEEREIQYAPLSFHKGEPQDLSGQEATNNEYSEIKIPK
  
Inhibitor
Name:
BDBM50230649
Synonyms:
CHEMBL3764071
Type:
Small organic molecule
Emp. Form.:
C23H39NO19
Mol. Mass.:
633.5511
SMILES:
[H][C@@]1(O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)O[C@H](CO[C@@]2(C[C@H](O)[C@@H](NC(C)=O)[C@@]([H])(O2)[C@H](O)[C@H](O)CO)C(O)=O)[C@H](O)[C@H](O)[C@H]1O |r|
Structure:
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