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Target
Glycine receptor subunit alpha-1
Ligand
BDBM50232889
Substrate
n/a
Meas. Tech.
ChEMBL_1649353 (CHEMBL3998487)
IC50
51±n/a nM
Citation
 Mohsen, AM; Mandour, YM; Sarukhanyan, E; Breitinger, U; Villmann, C; Banoub, MM; Breitinger, HG; Dandekar, T; Holzgrabe, U; Sotriffer, C; Jensen, AA; Zlotos, DP Oxime Ethers of (E)-11-Isonitrosostrychnine as Highly Potent Glycine Receptor Antagonists. J Nat Prod 79:2997-3005 (2016) [PubMed]  Article 
Target
Name:
Glycine receptor subunit alpha-1
Synonyms:
GLRA1 | GLRA1_HUMAN | Glycine receptor 48 kDa subunit | Glycine receptor strychnine-binding subunit
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52635.39
Organism:
Homo sapiens (Human)
Description:
P23415
Residue:
457
Sequence:
MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLFQEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ
  
Inhibitor
Name:
BDBM50232889
Synonyms:
CHEMBL4103909
Type:
Small organic molecule
Emp. Form.:
C24H23N3O3
Mol. Mass.:
401.4577
SMILES:
[H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])\C(=N/OCC#C)C(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |r,c:5|
Structure:
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