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Target
Sodium/hydrogen exchanger 1
Ligand
BDBM50234609
Substrate
n/a
Meas. Tech.
ChEMBL_1653456 (CHEMBL4002822)
IC50
172±n/a nM
Citation
 Singh, D; Silakari, O Sodium hydrogen exchanger inhibitory activity of benzotriazole derivatives. Eur J Med Chem 126:183-189 (2017) [PubMed]  Article 
Target
Name:
Sodium/hydrogen exchanger 1
Synonyms:
APNH | APNH1 | NHE-1 | NHE1 | Na(+)/H(+) antiporter, amiloride-sensitive | Na(+)/H(+) exchanger 1 | SL9A1_HUMAN | SLC9A1 | Solute carrier family 9 member 1
Type:
PROTEIN
Mol. Mass.:
90771.96
Organism:
Homo sapiens (Human)
Description:
ChEMBL_862405
Residue:
815
Sequence:
MVLRSGICGLSPHRIFPSLLVVVALVGLLPVLRSHGLQLSPTASTIRSSEPPRERSIGDVTTAPPEVTPESRPVNHSVTDHGMKPRKAFPVLGIDYTHVRTPFEISLWILLACLMKIGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDVFFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLMYAVCLVGGEQINNIGLLDNLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFANYEHVGIVDIFLGFLSFFVVALGGVLVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHHWNWTFVISTLLFCLIARVLGVLGLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSAVSTVSMQNIHPKSLPSERILPALSKDKEEEIRKILRNNLQKTRQRLRSYNRHTLVADPYEEAWNQMLLRRQKARQLEQKINNYLTVPAHKLDSPTMSRARIGSDPLAYEPKEDLPVITIDPASPQSPESVDLVNEELKGKVLGLSRDPAKVAEEDEDDDGGIMMRSKETSSPGTDDVFTPAPSDSPSSQRIQRCLSDPGPHPEPGEGEPFFPKGQ
  
Inhibitor
Name:
BDBM50234609
Synonyms:
Cariporide | HOE-642
Type:
Small organic molecule
Emp. Form.:
C12H17N3O3S
Mol. Mass.:
283.347
SMILES:
[#6]-[#6](-[#6])-c1ccc(cc1S([#6])(=O)=O)-[#6](=O)\[#7]=[#6](\[#7])-[#7]
Structure:
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