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Found 760 with Last Name = 'singh' and Initial = 'd'
TargetNeuropeptide Y receptor type 1(MOUSE)
Merck Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50091652(CHEMBL269503 | PYY | PYY, rat | Peptide YY(PYY)(YP...)
Affinity DataKi:  0.350nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Universiti Sains Malaysia

Curated by ChEMBL
LigandPNGBDBM21015((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Affinity DataKi:  0.403nMAssay Description:Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in HEK293 cells incubated for 120 mins by radiometric scintillation ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(MOUSE)
Merck Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM82276(L31,P34-NPY,human | NPY Leu31, Pro34, human, rat |...)
Affinity DataKi:  0.540nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50001765(8-chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]tri...)
Affinity DataKi:  0.680nMMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetGamma-aminobutyric acid receptor subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50017309(7-Chloro-3-(5-isopropyl-[1,2,4]oxadiazol-3-yl)-5-m...)
Affinity DataKi:  0.680nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeuropeptide Y receptor type 2(MOUSE)
Merck Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50091652(CHEMBL269503 | PYY | PYY, rat | Peptide YY(PYY)(YP...)
Affinity DataKi:  0.700nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50243981(Beta CCM | CHEMBL453066 | Methyl Beta-carboline-3 ...)
In DepthDetails PubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Nektar Therapeutics

US Patent
LigandPNGBDBM50027366(Ketazocine | US10081602, Example Ketazocine | US10...)
Affinity DataKi:  1.30nM ΔG°:  -50.7kJ/mole IC50:  5.60nMpH: 7.5 T: 2°CAssay Description:Competition binding experiments were conducted by incubating membrane protein to equilibrium in triplicate in the presence of a fixed concentration o...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Nektar Therapeutics

US Patent
LigandPNGBDBM50027366(Ketazocine | US10081602, Example Ketazocine | US10...)
Affinity DataKi:  1.30nMAssay Description:The binding affinities of certain compounds of the present invention were evaluated using radioligand binding assays in membranes prepared from CHO-K...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Nektar Therapeutics

US Patent
LigandPNGBDBM50027366(Ketazocine | US10081602, Example Ketazocine | US10...)
Affinity DataKi:  1.30nMpH: 7.5Assay Description:The binding affinities of certain compounds of the present invention were evaluated using radioligand binding assays in membranes prepared from CHO-K...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeuropeptide Y receptor type 2(MOUSE)
Merck Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50015490(CHEMBL438945 | H-YPSKPDNPGEDAPAEDMARYYSALRHYINLITR...)
Affinity DataKi:  1.80nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(MOUSE)
Merck Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM82287(NPY2-36 | NPY2-36, human | NPY2-36, porcine)
Affinity DataKi:  2.10nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 2(MOUSE)
Merck Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM82287(NPY2-36 | NPY2-36, human | NPY2-36, porcine)
Affinity DataKi:  2.5nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)
Affinity DataKi:  2.60nMMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
Nektar Therapeutics

US Patent
LigandPNGBDBM168148(US10081602, Example 20 | US10865186, Compound 20 |...)
Affinity DataKi:  2.86nM ΔG°:  -48.8kJ/molepH: 7.5 T: 2°CAssay Description:Competition binding experiments were conducted by incubating membrane protein to equilibrium in triplicate in the presence of a fixed concentration o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Nektar Therapeutics

US Patent
LigandPNGBDBM168148(US10081602, Example 20 | US10865186, Compound 20 |...)
Affinity DataKi:  2.86nMAssay Description:The binding affinities of certain compounds of the present invention were evaluated using radioligand binding assays in membranes prepared from CHO-K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Nektar Therapeutics

US Patent
LigandPNGBDBM168148(US10081602, Example 20 | US10865186, Compound 20 |...)
Affinity DataKi:  2.86nMpH: 7.5Assay Description:The binding affinities of certain compounds of the present invention were evaluated using radioligand binding assays in membranes prepared from CHO-K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Universiti Sains Malaysia

Curated by ChEMBL
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataKi:  4.20nMAssay Description:Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in HEK293 cells incubated for 120 mins by radiometric scintillation ana...More data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 5(Mus musculus (Mouse))
Merck Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50015490(CHEMBL438945 | H-YPSKPDNPGEDAPAEDMARYYSALRHYINLITR...)
Affinity DataKi:  4.30nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Nektar Therapeutics

US Patent
LigandPNGBDBM475934(Preparation of (2S,6R,11R)-8-((4-(2,5,8,11,14-pent...)
Affinity DataKi:  5nMAssay Description:The binding affinities of certain compounds of the present invention were evaluated using radioligand binding assays in membranes prepared from CHO-K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Nektar Therapeutics

US Patent
LigandPNGBDBM168147(US10081602, Example 12 | US9688638, 12)
Affinity DataKi:  5nMpH: 7.5Assay Description:The binding affinities of certain compounds of the present invention were evaluated using radioligand binding assays in membranes prepared from CHO-K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Nektar Therapeutics

US Patent
LigandPNGBDBM168147(US10081602, Example 12 | US9688638, 12)
Affinity DataKi:  5nM ΔG°:  -47.4kJ/molepH: 7.5 T: 2°CAssay Description:Competition binding experiments were conducted by incubating membrane protein to equilibrium in triplicate in the presence of a fixed concentration o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM25878(5-(2-fluorophenyl)-1-methyl-7-nitro-2,3-dihydro-1H...)
Affinity DataKi:  5.20nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeuropeptide Y receptor type 5(Mus musculus (Mouse))
Merck Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50091652(CHEMBL269503 | PYY | PYY, rat | Peptide YY(PYY)(YP...)
Affinity DataKi:  5.5nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Mus musculus (Mouse))
Merck Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM82276(L31,P34-NPY,human | NPY Leu31, Pro34, human, rat |...)
Affinity DataKi:  7.20nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Mus musculus (Mouse))
Merck Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM82287(NPY2-36 | NPY2-36, human | NPY2-36, porcine)
Affinity DataKi:  8.90nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 2(MOUSE)
Merck Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM82282(NPY13-36 | NPY13-36, porcine)
Affinity DataKi:  9.80nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM81951(CAS_104999 | DMCM | NSC_104999)
Affinity DataKi:  11.2nMMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50017320(8-Bromo-7-oxo-3b,4,5,6-tetrahydro-7H-2,6a,11b-tria...)
Affinity DataKi:  12.7nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Universiti Sains Malaysia

Curated by ChEMBL
LigandPNGBDBM50566312(CHEBI:70072 | Corynoxine)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in HEK293 cells incubated for 120 mins by radiometric scintillation ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)
Affinity DataKi:  16.8nMMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM26266(Ambien | CHEMBL911 | Dalparan | N,N-dimethyl-2-[6-...)
Affinity DataKi:  20.7nMMore data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 1(MOUSE)
Merck Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM82282(NPY13-36 | NPY13-36, porcine)
Affinity DataKi:  22nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Universiti Sains Malaysia

Curated by ChEMBL
LigandPNGBDBM168148(US10081602, Example 20 | US10865186, Compound 20 |...)
Affinity DataKi:  44nM ΔG°:  -42.0kJ/molepH: 7.5 T: 2°CAssay Description:Competition binding experiments were conducted by incubating membrane protein to equilibrium in triplicate in the presence of a fixed concentration o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Universiti Sains Malaysia

Curated by ChEMBL
LigandPNGBDBM168148(US10081602, Example 20 | US10865186, Compound 20 |...)
Affinity DataKi:  44.3nMpH: 7.5Assay Description:The binding affinities of certain compounds of the present invention were evaluated using radioligand binding assays in membranes prepared from CHO-K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Universiti Sains Malaysia

Curated by ChEMBL
LigandPNGBDBM168148(US10081602, Example 20 | US10865186, Compound 20 |...)
Affinity DataKi:  44.3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Universiti Sains Malaysia

Curated by ChEMBL
LigandPNGBDBM50519927(CHEMBL4546925)
Affinity DataKi:  55nMAssay Description:Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in HEK293 cells incubated for 120 mins by radiometric scintillation ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Universiti Sains Malaysia

Curated by ChEMBL
LigandPNGBDBM168147(US10081602, Example 12 | US9688638, 12)
Affinity DataKi:  58nM ΔG°:  -41.3kJ/molepH: 7.5 T: 2°CAssay Description:Competition binding experiments were conducted by incubating membrane protein to equilibrium in triplicate in the presence of a fixed concentration o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Universiti Sains Malaysia

Curated by ChEMBL
LigandPNGBDBM475934(Preparation of (2S,6R,11R)-8-((4-(2,5,8,11,14-pent...)
Affinity DataKi:  58.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Universiti Sains Malaysia

Curated by ChEMBL
LigandPNGBDBM168147(US10081602, Example 12 | US9688638, 12)
Affinity DataKi:  58.5nMpH: 7.5Assay Description:The binding affinities of certain compounds of the present invention were evaluated using radioligand binding assays in membranes prepared from CHO-K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50026756(3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triaz...)
Affinity DataKi:  89.5nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeuropeptide Y receptor type 5(Mus musculus (Mouse))
Merck Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM82282(NPY13-36 | NPY13-36, porcine)
Affinity DataKi:  109nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Universiti Sains Malaysia

Curated by ChEMBL
LigandPNGBDBM50566313(CHEBI:70070 | Corynoxine B)
Affinity DataKi:  110nMAssay Description:Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in HEK293 cells incubated for 120 mins by radiometric scintillation ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(MOUSE)
Merck Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM82286(CAS_59763-91-6 | PP, human | PP,SALMON)
Affinity DataKi:  122nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-6(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM81951(CAS_104999 | DMCM | NSC_104999)
Affinity DataKi:  134nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-6(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM26263(Anexate | CHEMBL407 | FLUMAZENIL | Ro15-1788 | Rom...)
Affinity DataKi:  148nMMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetMu-type opioid receptor(Homo sapiens (Human))
Universiti Sains Malaysia

Curated by ChEMBL
LigandPNGBDBM50474152(CHEBI:6956 | CHEMBL299031)
Affinity DataKi:  161nMAssay Description:Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in HEK293 cells incubated for 120 mins by radiometric scintillation ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Nektar Therapeutics

US Patent
LigandPNGBDBM168144(US10865186, Compound 4 | US9688638, 4 | US9688638,...)
Affinity DataKi:  203nM ΔG°:  -38.2kJ/mole IC50:  879nMpH: 7.5 T: 2°CAssay Description:Competition binding experiments were conducted by incubating membrane protein to equilibrium in triplicate in the presence of a fixed concentration o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Nektar Therapeutics

US Patent
LigandPNGBDBM168144(US10865186, Compound 4 | US9688638, 4 | US9688638,...)
Affinity DataKi:  203nMAssay Description:The binding affinities of certain compounds of the present invention were evaluated using radioligand binding assays in membranes prepared from CHO-K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Nektar Therapeutics

US Patent
LigandPNGBDBM285849((2S,6R,11R)-3-(Cyclopropylmethyl)-8-{2-[2-(2-metho...)
Affinity DataKi:  203nMpH: 7.5Assay Description:The binding affinities of certain compounds of the present invention were evaluated using radioligand binding assays in membranes prepared from CHO-K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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