Reaction Details
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N-acylethanolamine-hydrolyzing acid amidase
Ligand
BDBM50234744
Substrate
n/a
Meas. Tech.
ChEMBL_1653844 (CHEMBL4003210)
IC50
6.0±n/a nM
Citation
Petracca, R; Ponzano, S; Bertozzi, SM; Sasso, O; Piomelli, D; Bandiera, T; Bertozzi, F Progress in the development of฿-lactams as N-Acylethanolamine Acid Amidase (NAAA) inhibitors: Synthesis and SAR study of new, potent N-O-substituted derivatives. Eur J Med Chem 126:561-575 (2017) [PubMed] Article More Info.:
Target
Name:
N-acylethanolamine-hydrolyzing acid amidase
Synonyms:
ASAH-like protein | ASAHL | Acid ceramidase-like protein | N-acylethanolamine-hydrolyzing acid amidase | N-acylsphingosine amidohydrolase-like | N-acylsphingosine-amidohydrolase | NAAA | NAAA_HUMAN | PLT
Type:
Enzyme
Mol. Mass.:
40073.12
Organism:
Homo sapiens (Human)
Description:
Q02083
Residue:
359
Sequence:
MRTADREARPGLPSLLLLLLAGAGLSAASPPAAPRFNVSLDSVPELRWLPVLRHYDLDLVRAAMAQVIGDRVPKWVHVLIGKVVLELERFLPQPFTGEIRGMCDFMNLSLADCLLVNLAYESSVFCTSIVAQDSRGHIYHGRNLDYPFGNVLRKLTVDVQFLKNGQIAFTGTTFIGYVGLWTGQSPHKFTVSGDERDKGWWWENAIAALFRRHIPVSWLIRATLSESENFEAAVGKLAKTPLIADVYYIVGGTSPREGVVITRNRDGPADIWPLDPLNGAWFRVETNYDHWKPAPKEDDRRTSAIKALNATGQANLSLEALFQILSVVPVYNNFTIYTTVMSAGSPDKYMTRIRNPSRK
Inhibitor
Name:
BDBM50234744
Synonyms:
CHEMBL4101070
Type:
Small organic molecule
Emp. Form.:
C22H32N2O6S
Mol. Mass.:
452.564
SMILES:
C[C@H]1[C@H](NC(=O)OCCCCC2CCCCC2)C(=O)N1Oc1ccc(cc1)S(C)(=O)=O |r|
Structure:
