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Target
N-acylethanolamine-hydrolyzing acid amidase
Ligand
BDBM50151057
Substrate
n/a
Meas. Tech.
ChEMBL_1653841 (CHEMBL4003207)
IC50
28±n/a nM
Citation
 Petracca, R; Ponzano, S; Bertozzi, SM; Sasso, O; Piomelli, D; Bandiera, T; Bertozzi, F Progress in the development of฿-lactams as N-Acylethanolamine Acid Amidase (NAAA) inhibitors: Synthesis and SAR study of new, potent N-O-substituted derivatives. Eur J Med Chem 126:561-575 (2017) [PubMed]  Article 
Target
Name:
N-acylethanolamine-hydrolyzing acid amidase
Synonyms:
ASAH-like protein | Asahl | N-acylethanolamine acid amidase (NAAA) | N-acylethanolamine-hydrolyzing acid amidase | N-acylethanolamine-hydrolyzing acid amidase (NAAA) | N-acylethanolamine-hydrolyzing acid amidase subunit alpha | N-acylethanolamine-hydrolyzing acid amidase subunit beta | N-acylsphingosine amidohydrolase-like | NAAA_RAT | Naaa
Type:
Enzyme
Mol. Mass.:
40306.53
Organism:
Rattus norvegicus (Rat)
Description:
Q5KTC7
Residue:
362
Sequence:
MGTPAIRAACHGAHLALALLLLLSLSDPWLWATAPGTPPLFNVSLDAAPELRWLPMLQHYDPDFVRAAVAQVIGDRVPQWILEMIGEIVQKVESFLPQPFTSEIRGICDYLNLSLAEGVLVNLAYEASAFCTSIVAQDSQGRIYHGRNLDYPFGNALRKLTADVQFVKNGQIVFTATTFVGYVGLWTGQSPHKFTISGDERDKGWWWENMIAALSLGHSPISWLIRKTLTESEDFEAAVYTLAKTPLIADVYYIVGGTSPQEGVVITRDRGGPADIWPLDPLNGAWFRVETNYDHWEPVPKRDDRRTPAIKALNATGQAHLSLETLFQVLSVFPVYNNYTIYTTVMSAAEPDKYMTMIRNPS
  
Inhibitor
Name:
BDBM50151057
Synonyms:
CHEMBL3770726
Type:
Small organic molecule
Emp. Form.:
C14H24N2O3
Mol. Mass.:
268.352
SMILES:
O=C(N[C@H]1CNC1=O)OCCCCC1CCCCC1 |r|
Structure:
Search PDB for entries with ligand similarity: