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Target
Nuclear receptor ROR-beta
Ligand
BDBM50235619
Substrate
n/a
Meas. Tech.
ChEMBL_1657625 (CHEMBL4007095)
IC50
14300±n/a nM
Citation
 Nefzi, A; Marconi, GD; Ortiz, MA; Davis, JC; Piedrafita, FJ Synthesis of dihydroimidazole tethered imidazolinethiones and their activity as novel antagonists of the nuclear retinoic acid receptor-related orphan receptors (RORs). Bioorg Med Chem Lett 27:1608-1610 (2017) [PubMed]  Article 
Target
Name:
Nuclear receptor ROR-beta
Synonyms:
Nr1f2 | Nuclear receptor ROR-beta | Nuclear receptor RZR-beta | Nuclear receptor subfamily 1 group F member 2 | RORB_RAT | Retinoid-related orphan receptor-beta | Rorb | Rzrb
Type:
PROTEIN
Mol. Mass.:
53208.80
Organism:
Rattus norvegicus
Description:
ChEMBL_117326
Residue:
470
Sequence:
MCENQLKTKADGTAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNCLIDRTNRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQQQSGEAEALARVYSSSISNGLSNLNTETGGTYANGHVIDLPKSEGYYNIDSGQPSPDQSGLDMTGIKQIKQEPIYDLTSVHNLFTYSSFNNGQLAPGITMSEIDRIAQNIIKSHLETCQYTMEELHQLAWQTHTYEEIKAYQSKSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYGGMQMFKALGSDDLVNEAFDFAKNLCSLQLTEEEIALFSSAVLISPDRAWLLEPRKVQKLQEKIYFALQHVIQKNHLDDETLAKLIAKIPTITAVCNLHGEKLQVFKQSHPDIVNTLFPPLYKELFNPDCAAVCK
  
Inhibitor
Name:
BDBM50235619
Synonyms:
CHEMBL4073023
Type:
Small organic molecule
Emp. Form.:
C28H36N4S
Mol. Mass.:
460.677
SMILES:
C=CCC1=N[C@@H](CCCCN2C[C@H](Cc3ccccc3)N(CCc3ccccc3)C2=S)CN1 |r,t:3|
Structure:
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