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Target
P2X purinoceptor 7
Ligand
BDBM50237715
Substrate
n/a
Meas. Tech.
ChEBML_1662405
IC50
851±n/a nM
Citation
 O'Brien-Brown, J; Jackson, A; Reekie, TA; Barron, ML; Werry, EL; Schiavini, P; McDonnell, M; Munoz, L; Wilkinson, S; Noll, B; Wang, S; Kassiou, M Discovery and pharmacological evaluation of a novel series of adamantyl cyanoguanidines as P2X Eur J Med Chem 130:433-439 (2017) [PubMed]  Article 
Target
Name:
P2X purinoceptor 7
Synonyms:
ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor
Type:
Protein
Mol. Mass.:
68602.85
Organism:
Homo sapiens (Human)
Description:
Q99572
Residue:
595
Sequence:
MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISSVHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCPEYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPALLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGDNFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYKENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSSNCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRSLQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCGSCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDSTNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
  
Inhibitor
Name:
BDBM50237715
Synonyms:
CHEMBL4065826
Type:
Small organic molecule
Emp. Form.:
C21H28N4O
Mol. Mass.:
352.4732
SMILES:
COc1cccc(CN\C(NCC23CC4CC(CC(C4)C2)C3)=N\C#N)c1 |TLB:11:12:15:19.18.17,THB:20:18:15:13.21.12,20:12:15:19.18.17,17:18:13:15.16.21,17:16:13:19.20.18|
Structure:
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