Reaction Details Report a problem with these data
Target
Glutamate receptor 3
Ligand
BDBM85710
Substrate
n/a
Ki
57±n/a nM
Comments
PDSP_577
Citation
 Menniti, FS; Chenard, BL; Collins, MB; Ducat, MF; Elliott, ML; Ewing, FE; Huang, JI; Kelly, KA; Lazzaro, JT; Pagnozzi, MJ; Weeks, JL; Welch, WM; White, WF Characterization of the binding site for a novel class of noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonists. Mol Pharmacol 58:1310-7 (2000) [PubMed]  Article 
Target
Name:
Glutamate receptor 3
Synonyms:
GRIA3_RAT | Glur3 | Glutamate receptor 3 | Glutamate receptor ionotropic, AMPA 3 | Glutamate-AMPA | Gria3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
100383.57
Organism:
RAT
Description:
Glutamate-AMPA GRIA3 RAT::P19492
Residue:
888
Sequence:
MGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFPTDADVQFVIQMRPALKGAILSLLSYYKWEKFVYLYDTERGFSVLQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSSSSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI
  
Inhibitor
Name:
BDBM85710
Synonyms:
CP-471236
Type:
Small organic molecule
Emp. Form.:
C20H20N4OS
Mol. Mass.:
364.464
SMILES:
CC1NC(CS1)\C=C\c1nc2ccccc2c(=O)n1-c1cccnc1C |(16.26,-2.66,;14.78,-3.06,;13.53,-2.16,;12.28,-3.06,;12.76,-4.52,;14.3,-4.52,;11.08,-2.44,;11.08,-.9,;9.75,-.13,;8.41,-.9,;7.08,-.13,;5.75,-.9,;4.41,-.13,;4.41,1.41,;5.75,2.18,;7.08,1.41,;8.41,2.18,;8.41,3.72,;9.75,1.41,;11.08,2.18,;12.42,1.41,;13.75,2.18,;13.75,3.72,;12.42,4.49,;11.08,3.72,;9.75,4.49,)|
Structure:
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