Reaction Details Report a problem with these data
Target
Histamine H4 receptor
Ligand
BDBM50017721
Substrate
n/a
Ki
>10000±n/a nM
Comments
PDSP_606
Citation
 Liu, C; Ma, X; Jiang, X; Wilson, SJ; Hofstra, CL; Blevitt, J; Pyati, J; Li, X; Chai, W; Carruthers, N; Lovenberg, TW Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol Pharmacol 59:420-6 (2001) [PubMed]  Article 
Target
Name:
Histamine H4 receptor
Synonyms:
AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44517.02
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:
390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
  
Inhibitor
Name:
BDBM50017721
Synonyms:
1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)piperidine | 1-methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine | 4-(5-dibenzo(a,d)cyclohepten-5-ylidine)-1-methylpiperidine | 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidine | 4-(5H-dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine | 5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclopheptene | CHEMBL516 | CYPROHEPTADINE
Type:
Small organic molecule
Emp. Form.:
C21H21N
Mol. Mass.:
287.3981
SMILES:
[#6]-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1/c2ccccc2-[#6]=[#6]-c2ccccc-12 |c:16|
Structure:
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