Reaction Details Report a problem with these data
Target
Beta-2-microglobulin
Ligand
BDBM92395
Substrate
n/a
Meas. Tech.
Fluorescence Assay
pH
7.4±0
Temperature
310.15±0 K
IC50
9.8e+4± 1.2e+4 nM
Citation
 Giorgetti, S; Raimondi, S; Pagano, K; Relini, A; Bucciantini, M; Corazza, A; Fogolari, F; Codutti, L; Salmona, M; Mangione, P; Colombo, L; De Luigi, A; Porcari, R; Gliozzi, A; Stefani, M; Esposito, G; Bellotti, V; Stoppini, M Effect of tetracyclines on the dynamics of formation and destructuration of beta2-microglobulin amyloid fibrils. J Biol Chem 286:2121-31 (2011) [PubMed]  Article 
Target
Name:
Beta-2-microglobulin
Synonyms:
B2M | B2MG_HUMAN
Type:
Enzyme
Mol. Mass.:
13714.40
Organism:
Homo sapiens (Human)
Description:
P61769
Residue:
119
Sequence:
MSRSVALAVLALLSLSGLEAIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM
  
Inhibitor
Name:
BDBM92395
Synonyms:
Meclocycline
Type:
Small organic molecule
Emp. Form.:
C22H21ClN2O8
Mol. Mass.:
476.864
SMILES:
CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(C(=O)c4c(O)ccc(Cl)c4C3=C)C(=O)[C@]2(O)C(=O)C(C(N)=O)C1=O
Structure:
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