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Target
Ubiquitin-like modifier-activating enzyme 1 [957-994]
Ligand
BDBM92475
Substrate
n/a
Meas. Tech.
Ubiquitin Thioester Inhibtion Assay
IC50
10.2±1.7 nM
Citation
 Chen, JJ; Tsu, CA; Gavin, JM; Milhollen, MA; Bruzzese, FJ; Mallender, WD; Sintchak, MD; Bump, NJ; Yang, X; Ma, J; Loke, HK; Xu, Q; Li, P; Bence, NF; Brownell, JE; Dick, LR Mechanistic studies of substrate-assisted inhibition of ubiquitin-activating enzyme by adenosine sulfamate analogues. J Biol Chem 286:40867-77 (2011) [PubMed]  Article 
Target
Name:
Ubiquitin-like modifier-activating enzyme 1 [957-994]
Synonyms:
A1S9T | UBA1 | UBA1_HUMAN | UBE1 | Ubiquitin activating enzyme (UAE)
Type:
Enzyme
Mol. Mass.:
4484.57
Organism:
Homo sapiens (Human)
Description:
Q712V1
Residue:
38
Sequence:
RFEVQGLQPNGEEMTLKQFLDYFKTEHKLEITMLSQGV
  
Inhibitor
Name:
BDBM92475
Synonyms:
Compound I
Type:
Small organic molecule
Emp. Form.:
C19H22N6O6S
Mol. Mass.:
462.48
SMILES:
NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NC3CCc4ccccc34)ncnc12 |r|
Structure:
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