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Target
Serine/threonine-protein kinase D3
Ligand
BDBM32334
Substrate
n/a
Meas. Tech.
In Vitro Radiometric PKD Assay
pH
7.5±0
Temperature
303.15±0 K
IC50
227±24 nM
Citation
 Sharlow, ER; Giridhar, KV; LaValle, CR; Chen, J; Leimgruber, S; Barrett, R; Bravo-Altamirano, K; Wipf, P; Lazo, JS; Wang, QJ Potent and selective disruption of protein kinase D functionality by a benzoxoloazepinolone. J Biol Chem 283:33516-26 (2008) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase D3
Synonyms:
EPK2 | KPCD3_HUMAN | PRKCN | PRKD3 | Protein kinase C nu | Protein kinase C nu type | Protein kinase C, PKC | Protein kinase C, PKC; classical/novel | Protein kinase EPK2 | Serine/threonine-protein kinase D3 (PKD3) | classical/novel | nPKC-nu
Type:
Enzyme Catalytic Domain
Mol. Mass.:
100475.64
Organism:
Homo sapiens (Human)
Description:
gi_5031689
Residue:
890
Sequence:
MSANNSPPSAQKSVLPTAIPAVLPAASPCSSPKTGLSARLSNGSFSAPSLTNSRGSVHTVSFLLQIGLTRESVTIEAQELSLSAVKDLVCSIVYQKFPECGFFGMYDKILLFRHDMNSENILQLITSADEIHEGDLVEVVLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSNVSLPGPGLSVPRPLQPEYVALPSEESHVHQEPSKRIPSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDCLGEVTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGLDDTEEPSPPEDKMFFLDPSDLDVERDEEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMVKEGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEILRISSPRDFTNISQGSNPHCFEIITDTMVYFVGENNGDSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQASVCTSPGQGKDHKDLSTSISVSNCQIQENVDISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLDLREFETRIGERYITHESDDARWEIHAYTHNLVYPKHFIMAPNPDDMEEDP
  
Inhibitor
Name:
BDBM32334
Synonyms:
7-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c]azepin-1-one | 7-hydroxy-2,3,4,5-tetrahydro-[1]benzofuro[2,3-c]azepin-1-one | 7-hydroxy-2,3,4,5-tetrahydrobenzofur[2,3-c]azepin-1-one | 7-hydroxy-2,3,4,5-tetrahydrobenzofuro[2,3-c]azepin-1-one | 7-oxidanyl-2,3,4,5-tetrahydro-[1]benzofuro[2,3-c]azepin-1-one | MLS000043346 | SMR000019965 | cid_755673
Type:
Small organic molecule
Emp. Form.:
C12H11NO3
Mol. Mass.:
217.2206
SMILES:
Oc1ccc2oc3c(CCCNC3=O)c2c1
Structure:
Search PDB for entries with ligand similarity: