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Found 90 with Last Name = 'bravo-altamirano' and Initial = 'k'
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM50336960(3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-th...)
Affinity DataIC50:  28.3nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM50336960(3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-th...)
Affinity DataIC50:  28.3nMAssay Description:Inhibition of human recombinant PKD1 after 10 mins by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycystin-2(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50336958(2-Methoxy-7H,8H,9H-1,4-thiazepino[7',6'-5,4]thioph...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human recombinant PKD2 after 10 mins by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D3(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM50336960(3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-th...)
Affinity DataIC50:  53.2nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D2(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM50336960(3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-th...)
Affinity DataIC50:  58.7nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D3(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM50336962(2,3,4,5-Tetrahydro-10-hydroxybenzo[b]thieno[2,3-f]...)
Affinity DataIC50:  58.8nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM50336961(3,4-Dihydro-9-azido-[1]benzothieno[2,3-f]-1,4-thia...)
Affinity DataIC50:  74.9nMAssay Description:Inhibition of human recombinant PKD1 after 10 mins by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM50119286(3-Methoxy-7,8-dihydro-6H-5,10-dithia-8-aza-benzo[a...)
Affinity DataIC50:  82.5nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM50119286(3-Methoxy-7,8-dihydro-6H-5,10-dithia-8-aza-benzo[a...)
Affinity DataIC50:  82.5nMAssay Description:Inhibition of human recombinant PKD1 after 10 mins by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D3(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM81614(kb-NB165-31)
Affinity DataIC50:  91.1nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D3(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM50119286(3-Methoxy-7,8-dihydro-6H-5,10-dithia-8-aza-benzo[a...)
Affinity DataIC50:  98.5nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D2(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM50336962(2,3,4,5-Tetrahydro-10-hydroxybenzo[b]thieno[2,3-f]...)
Affinity DataIC50:  101nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM50336962(2,3,4,5-Tetrahydro-10-hydroxybenzo[b]thieno[2,3-f]...)
Affinity DataIC50:  111nMAssay Description:Inhibition of human recombinant PKD1 after 10 mins by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM50336962(2,3,4,5-Tetrahydro-10-hydroxybenzo[b]thieno[2,3-f]...)
Affinity DataIC50:  111nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM81614(kb-NB165-31)
Affinity DataIC50:  114nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM50336958(2-Methoxy-7H,8H,9H-1,4-thiazepino[7',6'-5,4]thioph...)
Affinity DataIC50:  124nMAssay Description:Inhibition of human recombinant PKD1 after 10 mins by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM50336959(3,4,5,10-Tetrahydro-7-hydroxy-azepino[3,4-b]indol-...)
Affinity DataIC50:  130nMAssay Description:Inhibition of human recombinant PKD1 after 10 mins by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D2(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM50119286(3-Methoxy-7,8-dihydro-6H-5,10-dithia-8-aza-benzo[a...)
Affinity DataIC50:  142nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D2(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM81614(kb-NB165-31)
Affinity DataIC50:  163nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM32334(7-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c...)
Affinity DataIC50:  182nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM32334(7-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c...)
Affinity DataIC50:  182nMpH: 7.5 T: 2°CAssay Description:The radiometric kinase assay using PKD kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM32334(7-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c...)
Affinity DataIC50:  182nMAssay Description:Inhibition of human recombinant PKD1 after 10 mins by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM50336963(2,3,4,5-Tetrahydro-10-methoxybenzo[b]thieno[2,3-f]...)
Affinity DataIC50:  193nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM50336963(2,3,4,5-Tetrahydro-10-methoxybenzo[b]thieno[2,3-f]...)
Affinity DataIC50:  193nMAssay Description:Inhibition of human recombinant PKD1 after 10 mins by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D3(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM32334(7-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c...)
Affinity DataIC50:  227nMpH: 7.5 T: 2°CAssay Description:The radiometric kinase assay using PKD kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D3(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM32334(7-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c...)
Affinity DataIC50:  227nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D2(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM32334(7-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c...)
Affinity DataIC50:  280nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycystin-2(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM32334(7-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c...)
Affinity DataIC50:  280nMAssay Description:Inhibition of human recombinant PKD2 after 10 mins by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D2(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM32334(7-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c...)
Affinity DataIC50:  280nMpH: 7.5 T: 2°CAssay Description:The radiometric kinase assay using PKD kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D3(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM50336963(2,3,4,5-Tetrahydro-10-methoxybenzo[b]thieno[2,3-f]...)
Affinity DataIC50:  325nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D2(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM50336963(2,3,4,5-Tetrahydro-10-methoxybenzo[b]thieno[2,3-f]...)
Affinity DataIC50:  463nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM32334(7-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c...)
Affinity DataIC50:  500nMAssay Description:An IMAP-based PKD HTS FR assay was used for primary HTS of the PMLSC library to identify hit compounds and subsequent secondary hit confirmation stud...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM92601(CID 797718)
Affinity DataIC50:  2.13E+3nMpH: 7.5 T: 2°CAssay Description:The radiometric kinase assay using PKD kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM50336961(3,4-Dihydro-9-azido-[1]benzothieno[2,3-f]-1,4-thia...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of PKD1 autophosphorylation at Ser916 in human PMA-induced LNCAP cells by Western blottingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM50336960(3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-th...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of PKD1 autophosphorylation at Ser916 in human PMA-induced LNCAP cells by Western blottingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM50336962(2,3,4,5-Tetrahydro-10-hydroxybenzo[b]thieno[2,3-f]...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of PKD1 autophosphorylation at Ser916 in human PMA-induced LNCAP cells by Western blottingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM50119286(3-Methoxy-7,8-dihydro-6H-5,10-dithia-8-aza-benzo[a...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of PKD1 autophosphorylation at Ser916 in human PMA-induced LNCAP cells by Western blottingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM50336958(2-Methoxy-7H,8H,9H-1,4-thiazepino[7',6'-5,4]thioph...)
Affinity DataIC50:  6.80E+3nMAssay Description:Inhibition of PKD1 autophosphorylation at Ser916 in human PMA-induced LNCAP cells by Western blottingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM92601(CID 797718)
Affinity DataIC50:  7.00E+3nMAssay Description:An IMAP-based PKD HTS FR assay was used for primary HTS of the PMLSC library to identify hit compounds and subsequent secondary hit confirmation stud...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 7(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM92601(CID 797718)
Affinity DataIC50:  8.40E+3nMAssay Description:An IMAP-based PKD HTS FR assay was used for primary HTS of the PMLSC library to identify hit compounds and subsequent secondary hit confirmation stud...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM32334(7-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c...)
Affinity DataIC50:  1.18E+4nMAssay Description:Inhibition of PKD1 autophosphorylation at Ser916 in human PMA-induced LNCAP cells by Western blottingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 7(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM32334(7-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c...)
Affinity DataIC50:  1.53E+4nMAssay Description:An IMAP-based PKD HTS FR assay was used for primary HTS of the PMLSC library to identify hit compounds and subsequent secondary hit confirmation stud...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM50336963(2,3,4,5-Tetrahydro-10-methoxybenzo[b]thieno[2,3-f]...)
Affinity DataIC50:  1.86E+4nMAssay Description:Inhibition of PKD1 autophosphorylation at Ser916 in human PMA-induced LNCAP cells by Western blottingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM32334(7-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c...)
Affinity DataIC50:  2.03E+4nMAssay Description:An IMAP-based PKD HTS FR assay was used for primary HTS of the PMLSC library to identify hit compounds and subsequent secondary hit confirmation stud...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM92601(CID 797718)
Affinity DataIC50:  2.19E+4nMAssay Description:An IMAP-based PKD HTS FR assay was used for primary HTS of the PMLSC library to identify hit compounds and subsequent secondary hit confirmation stud...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM92601(CID 797718)
Affinity DataIC50: >5.00E+4nMAssay Description:An IMAP-based PKD HTS FR assay was used for primary HTS of the PMLSC library to identify hit compounds and subsequent secondary hit confirmation stud...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM32334(7-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c...)
Affinity DataIC50: >5.00E+4nMAssay Description:An IMAP-based PKD HTS FR assay was used for primary HTS of the PMLSC library to identify hit compounds and subsequent secondary hit confirmation stud...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM50336959(3,4,5,10-Tetrahydro-7-hydroxy-azepino[3,4-b]indol-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of PKD1 autophosphorylation at Ser916 in human PMA-induced LNCAP cells by Western blottingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50366800(OLOMOUCINE II)
Affinity DataEC50:  8.00E+4nMAssay Description:Agonist activity at N-type Cav2.2 channel expressed in tsA201 cell assessed as calcium current by whole-cell patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400563(CHEMBL2206241)
Affinity DataEC50:  3.00E+4nMAssay Description:Agonist activity at N-type Cav2.2 channel expressed in tsA201 cell assessed as calcium current by whole-cell patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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