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Target
Proto-oncogene tyrosine-protein kinase Src
Ligand
BDBM50193910
Substrate
n/a
Meas. Tech.
Luciferase-Based Assay
Temperature
298.15±n/a K
IC50
10.2±0.0 nM
Comments
extracted
Citation
Gong, X; Barrett, K; Cao, J; Gritzen, C; Noronha, G; Hood, JD; Mak, CC; McPherson, A; Pathak, VP; Renick, J; Soll, RM; Splittgerber, U; Wrasidlo, W; Zeng, B; Zhao, N; Dneprovskaia, E Benzotriazine inhibitors of kinases US Patent US8481536 Publication Date 7/9/2013
More Info.:
Target
Name:
Proto-oncogene tyrosine-protein kinase Src
Synonyms:
Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src
Type:
Protein
Mol. Mass.:
59838.60
Organism:
Homo sapiens (Human)
Description:
P12931
Residue:
536
Sequence:
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
Inhibitor
Name:
BDBM50193910
Synonyms:
CHEMBL218102 | N-(3-(2-(diethylamino)ethoxy)phenyl)-7-(2,6-dimethylphenyl)-5-methylbenzo[e][1,2,4]triazin-3-amine | US8481536, 370
Type:
Small organic molecule
Emp. Form.:
C28H33N5O
Mol. Mass.:
455.5945
SMILES:
CCN(CC)CCOc1cccc(Nc2nnc3cc(cc(C)c3n2)-c2c(C)cccc2C)c1