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Target
Tyrosine-protein kinase Yes
Ligand
BDBM50193883
Substrate
n/a
Meas. Tech.
Luciferase-Based Assay
Temperature
298.15±n/a K
IC50
822±0.0 nM
Comments
extracted
Citation
 Gong, X; Barrett, K; Cao, J; Gritzen, C; Noronha, G; Hood, JD; Mak, CC; McPherson, A; Pathak, VP; Renick, J; Soll, RM; Splittgerber, U; Wrasidlo, W; Zeng, B; Zhao, N; Dneprovskaia, E Benzotriazine inhibitors of kinases US Patent  US8481536 Publication Date 7/9/2013 
Target
Name:
Tyrosine-protein kinase Yes
Synonyms:
Proto-oncogene c-Yes | VHL/Tyrosine-protein kinase Yes | YES | YES1 | YES_HUMAN | p61-yes
Type:
Protein
Mol. Mass.:
60801.54
Organism:
Homo sapiens (Human)
Description:
P07947
Residue:
543
Sequence:
MGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMTPFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPGENL
  
Inhibitor
Name:
BDBM50193883
Synonyms:
7-(2,6-dimethylphenyl)-N-phenylbenzo[e][1,2,4]triazin-3-amine | CHEMBL218042 | US8481536, 314 | US8481536, 572
Type:
Small organic molecule
Emp. Form.:
C21H18N4
Mol. Mass.:
326.3944
SMILES:
Cc1cccc(C)c1-c1ccc2nc(Nc3ccccc3)nnc2c1
Structure:
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