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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM50299250
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
6.6e+2±n/a nM
Citation
 Anizon, F; Moreau, P; Prudhomme, M; Cohen, P; Aboab, B; Akue-Gedu, R; Rossignol, E Pyrrolo[2,3-a] carbazoles and use thereof as PIM kinase inhibitors US Patent  US8481586 Publication Date 7/9/2013 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM50299250
Synonyms:
7-(2,4-Difluorophenyl)-1,10-dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde | CHEMBL575739 | US8481586, 40
Type:
Small organic molecule
Emp. Form.:
C21H12F2N2O
Mol. Mass.:
346.3296
SMILES:
Fc1ccc(c(F)c1)-c1ccc2[nH]c3c(ccc4c(C=O)c[nH]c34)c2c1
Structure:
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