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Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM50299247
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
1.7e+2±n/a nM
Citation
 Anizon, F; Moreau, P; Prudhomme, M; Cohen, P; Aboab, B; Akue-Gedu, R; Rossignol, E Pyrrolo[2,3-a] carbazoles and use thereof as PIM kinase inhibitors US Patent  US8481586 Publication Date 7/9/2013 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM50299247
Synonyms:
1-(1,10-Dihydropyrrolo[2,3-a]carbazol-3-yl)-2,2,2-trifluoroethanone | CHEMBL583788 | US8481586, 6
Type:
Small organic molecule
Emp. Form.:
C16H9F3N2O
Mol. Mass.:
302.2507
SMILES:
FC(F)(F)C(=O)c1c[nH]c2c1ccc1c3ccccc3[nH]c21
Structure:
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