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Target
Mitogen-activated protein kinase 8
Ligand
BDBM100613
Substrate
n/a
Meas. Tech.
In Vitro Enzyme Assay
IC50
1.4e+2±n/a nM
Citation
 Bilotta, JA; Cheung, AW; Firooznia, F; Guertin, KR; Hayden, S; Haynes, N; Lukacs-Lesburg, CM; Marcopulos, N; Mertz, E; Qi, L; Qian, Y; So, S; Tan, J; Thakkar, KC Aminomethyl quinolone compounds US Patent  US8501732 Publication Date 8/6/2013 
Target
Name:
Mitogen-activated protein kinase 8
Synonyms:
JNK-46 | JNK1 | JNK1-alpha-1 | MAPK8 | MK08_HUMAN | Mitogen-Activated Protein Kinase 8 (JNK1) | PRKM8 | SAPK1 | SAPK1C | Stress-activated protein kinase JNK1 | c-Jun N-terminal kinase 1 | c-Jun N-terminal kinase 1 (JNK1) | c-Jun N-terminal kinase 1(JNK1) | c-Jun N-terminal kinase 2 (JNK2)
Type:
Enzyme
Mol. Mass.:
48297.57
Organism:
Homo sapiens (Human)
Description:
JNK-1 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology).
Residue:
427
Sequence:
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAAGPLGCCR
  
Inhibitor
Name:
BDBM100613
Synonyms:
US8501732, 519 | US8501732, I-173 | US8501732, I-174
Type:
Small organic molecule
Emp. Form.:
C25H24ClN5O
Mol. Mass.:
445.944
SMILES:
Clc1ccc2c(c1)n(cc(CNc1cc(ncn1)N1CCCCC1)c2=O)-c1ccccc1
Structure:
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