Reaction Details Report a problem with these data
Target
Cathepsin S
Ligand
BDBM2736
Substrate
n/a
Meas. Tech.
Enzyme Inhbition Assay
IC50
0.155±n/a nM
Citation
 Banner, D; Grether, U; Haap, W; Kuehne, H; Mauser, H; Plancher, J Pyrrolidine derivatives US Patent  US8524710 Publication Date 9/3/2013 
Target
Name:
Cathepsin S
Synonyms:
CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:
Protein
Mol. Mass.:
37507.38
Organism:
Homo sapiens (Human)
Description:
P25774
Residue:
331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
  
Inhibitor
Name:
BDBM2736
Synonyms:
US8524710, 80
Type:
n/a
Emp. Form.:
C24H18Cl2F3N5O3S
Mol. Mass.:
584.398
SMILES:
FC(F)(F)c1ccc(CNC(=O)c2cnc(nc2N2CC[C@@H](C2)S(=O)(=O)c2cccc(Cl)c2Cl)C#N)cc1 |r|
Structure:
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