Reaction Details Report a problem with these data
Target
Dihydrolipoyl dehydrogenase
Ligand
BDBM119878
Substrate
n/a
Meas. Tech.
Enzyme Assays
Ki
140±9 nM
Citation
 Bryk, R; Arango, N; Maksymiuk, C; Balakrishnan, A; Wu, YT; Wong, CH; Masquelin, T; Hipskind, P; Lima, CD; Nathan, C Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase. Biochemistry 52:9375-84 (2013) [PubMed]  Article 
Target
Name:
Dihydrolipoyl dehydrogenase
Synonyms:
Component of peroxynitrite reductase/peroxidase complex | DLDH_MYCTO | Dihydrolipoyl dehydrogenase (Lpd) | Dihydrolipoyl dehydrogenase (Lpd) A181V | Dihydrolipoyl dehydrogenase (Lpd) A290R | Dihydrolipoyl dehydrogenase (Lpd) F269R | Dihydrolipoyl dehydrogenase (Lpd) G312A, L313G, L314P, Q315M | Dihydrolipoyl dehydrogenase (Lpd) L314P | Dihydrolipoyl dehydrogenase (Lpd) N209V | Dihydrolipoyl dehydrogenase (Lpd) R147T | Dihydrolipoyl dehydrogenase (Lpd) R347S | Lipoamide dehydrogenase (Lpd) | lpd | lpdC
Type:
Enzyme
Mol. Mass.:
49231.98
Organism:
Mycobacterium tuberculosis
Description:
P9WHH8
Residue:
464
Sequence:
MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNVGCIPSKALLRNAELVHIFTKDAKAFGISGEVTFDYGIAYDRSRKVAEGRVAGVHFLMKKNKITEIHGYGTFADANTLLVDLNDGGTESVTFDNAIIATGSSTRLVPGTSLSANVVTYEEQILSRELPKSIIIAGAGAIGMEFGYVLKNYGVDVTIVEFLPRALPNEDADVSKEIEKQFKKLGVTILTATKVESIADGGSQVTVTVTKDGVAQELKAEKVLQAIGFAPNVEGYGLDKAGVALTDRKAIGVDDYMRTNVGHIYAIGDVNGLLQLAHVAEAQGVVAAETIAGAETLTLGDHRMLPRATFCQPNVASFGLTEQQARNEGYDVVVAKFPFTANAKAHGVGDPSGFVKLVADAKHGELLGGHLVGHDVAELLPELTLAQRWDLTASELARNVHTHPTMSEALQECFHGLVGHMINF
  
Inhibitor
Name:
BDBM119878
Synonyms:
SL827 | US9073941, 500
Type:
Small organic molecule
Emp. Form.:
C15H17BrN4O4S
Mol. Mass.:
429.289
SMILES:
COc1ccc(NC(=O)CN(C)S(=O)(=O)c2cc(Br)cnc2N)cc1
Structure:
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