Affinity DataKi: 37nMAssay Description:IC50 values were determined with serial dilutions (from 100 to 0.1 uM) of inhibitors by a spectrophotometric assay with DTNB, lipoamide, and NADH or ...More data for this Ligand-Target Pair
Affinity DataKi: 78nMAssay Description:IC50 values were determined with serial dilutions (from 100 to 0.1 uM) of inhibitors by a spectrophotometric assay with DTNB, lipoamide, and NADH or ...More data for this Ligand-Target Pair
Affinity DataKi: 93nMAssay Description:IC50 values were determined with serial dilutions (from 100 to 0.1 uM) of inhibitors by a spectrophotometric assay with DTNB, lipoamide, and NADH or ...More data for this Ligand-Target Pair
Affinity DataKi: 140nMAssay Description:IC50 values were determined with serial dilutions (from 100 to 0.1 uM) of inhibitors by a spectrophotometric assay with DTNB, lipoamide, and NADH or ...More data for this Ligand-Target Pair
Affinity DataKi: 143nMAssay Description:IC50 values were determined with serial dilutions (from 100 to 0.1 uM) of inhibitors by a spectrophotometric assay with DTNB, lipoamide, and NADH or ...More data for this Ligand-Target Pair
Affinity DataKi: 155nMAssay Description:IC50 values were determined with serial dilutions (from 100 to 0.1 uM) of inhibitors by a spectrophotometric assay with DTNB, lipoamide, and NADH or ...More data for this Ligand-Target Pair
Affinity DataKi: 155nMAssay Description:IC50 values were determined with serial dilutions (from 100 to 0.1 uM) of inhibitors by a spectrophotometric assay with DTNB, lipoamide, and NADH or ...More data for this Ligand-Target Pair
Affinity DataKi: 233nMAssay Description:IC50 values were determined with serial dilutions (from 100 to 0.1 uM) of inhibitors by a spectrophotometric assay with DTNB, lipoamide, and NADH or ...More data for this Ligand-Target Pair
Affinity DataKi: 289nMAssay Description:IC50 values were determined with serial dilutions (from 100 to 0.1 uM) of inhibitors by a spectrophotometric assay with DTNB, lipoamide, and NADH or ...More data for this Ligand-Target Pair
Affinity DataKi: 333nMAssay Description:IC50 values were determined with serial dilutions (from 100 to 0.1 uM) of inhibitors by a spectrophotometric assay with DTNB, lipoamide, and NADH or ...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataKi: 420nMAssay Description:Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataKi: 520nMAssay Description:Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataKi: 760nMAssay Description:Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataKi: 1.10E+3nMAssay Description:Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataKi: 1.10E+3nMAssay Description:Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataKi: 1.20E+3nMAssay Description:Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataKi: 1.40E+3nMAssay Description:Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataKi: 1.70E+3nMAssay Description:Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataKi: 1.80E+3nMAssay Description:Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataKi: 2.00E+3nMAssay Description:Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min...More data for this Ligand-Target Pair
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataKi: 3.40E+3nMAssay Description:Competitive inhibition of human recombinant PKRMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataKi: 3.50E+3nMAssay Description:Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataKi: 3.50E+3nMAssay Description:Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataKi: 6.00E+3nMAssay Description:Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataKi: 7.90E+3nMAssay Description:Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 min...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activityMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activityMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activityMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activityMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activityMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activityMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activityMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activityMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataIC50: 4.40nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activityMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activityMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activityMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataIC50: 5.70nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activityMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataIC50: 7.20nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activityMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activityMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activityMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activityMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activity in human KARPAS-1106P cells incubated for 2 hrs by proteasome-Glo assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activityMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Experiments to determine IC50 values against β5i and β5c for compounds were carried out in 96-well plates. In brief, 1 μL of compound ...More data for this Ligand-Target Pair
Ligand Info
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activityMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activityMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activityMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activityMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activity in human KARPAS-1106P cells incubated for 2 hrs by proteasome-Glo assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Weill Cornell Medical College
Curated by ChEMBL
Weill Cornell Medical College
Curated by ChEMBL
Affinity DataIC50: 26nMAssay Description:Inhibition of human 20S proteasome subunit beta-5i using Ac-ANW-AMC as substrate and measured every 30 secs for 30 mins by microtiter plate assayMore data for this Ligand-Target Pair