Reaction Details Report a problem with these data
Target
Prephenate dehydrogenase
Ligand
BDBM119877
Substrate
n/a
Meas. Tech.
Enzyme Assays
Ki
155±12 nM
Citation
 Bryk, R; Arango, N; Maksymiuk, C; Balakrishnan, A; Wu, YT; Wong, CH; Masquelin, T; Hipskind, P; Lima, CD; Nathan, C Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase. Biochemistry 52:9375-84 (2013) [PubMed]  Article 
Target
Name:
Prephenate dehydrogenase
Synonyms:
Prephenate dehydrogenase TyrA (PDH) | TYRA_MYCTU | tyrA
Type:
Protein
Mol. Mass.:
33096.86
Organism:
Mycobacterium tuberculosis H37Rv
Description:
O69721
Residue:
323
Sequence:
MTRTVAAPPVCVLGLGLIGGSIMRAAAAAGREVFGYNRSVEGAHGARSDGFDAITDLNQTLTRAAATEALIVLAVPMPALPGMLAHIRKSAPGCPLTDVTSVKCAVLDEVTAAGLQARYVGGHPMTGTAHSGWTAGHGGLFNRAPWVVSVDDHVDPTVWSMVMTLALDCGAMVVPAKSDEHDAAAAAVSHLPHLLAEALAVTAAEVPLAFALAAGSFRDATRVAATAPDLVRAMCEANTGQLAPAADRIIDLLSRARDSLQSHGSIADLADAGHAARTRYDSFPRSDIVTVVIGADKWREQLAAAGRAGGVITSALPSLDSPQ
  
Inhibitor
Name:
BDBM119877
Synonyms:
SL809 | US9073941, 502
Type:
Small organic molecule
Emp. Form.:
C16H19BrN4O5S
Mol. Mass.:
459.315
SMILES:
COc1ccc(NC(=O)CN(C)S(=O)(=O)c2cc(Br)cnc2N)cc1OC
Structure:
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