Reaction Details Report a problem with these data
Target
Prephenate dehydrogenase
Ligand
BDBM119880
Substrate
n/a
Meas. Tech.
Enzyme Assays
Ki
333±28 nM
Citation
 Bryk, R; Arango, N; Maksymiuk, C; Balakrishnan, A; Wu, YT; Wong, CH; Masquelin, T; Hipskind, P; Lima, CD; Nathan, C Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase. Biochemistry 52:9375-84 (2013) [PubMed]  Article 
Target
Name:
Prephenate dehydrogenase
Synonyms:
Prephenate dehydrogenase TyrA (PDH) | TYRA_MYCTU | tyrA
Type:
Protein
Mol. Mass.:
33096.86
Organism:
Mycobacterium tuberculosis H37Rv
Description:
O69721
Residue:
323
Sequence:
MTRTVAAPPVCVLGLGLIGGSIMRAAAAAGREVFGYNRSVEGAHGARSDGFDAITDLNQTLTRAAATEALIVLAVPMPALPGMLAHIRKSAPGCPLTDVTSVKCAVLDEVTAAGLQARYVGGHPMTGTAHSGWTAGHGGLFNRAPWVVSVDDHVDPTVWSMVMTLALDCGAMVVPAKSDEHDAAAAAVSHLPHLLAEALAVTAAEVPLAFALAAGSFRDATRVAATAPDLVRAMCEANTGQLAPAADRIIDLLSRARDSLQSHGSIADLADAGHAARTRYDSFPRSDIVTVVIGADKWREQLAAAGRAGGVITSALPSLDSPQ
  
Inhibitor
Name:
BDBM119880
Synonyms:
SL418
Type:
Small organic molecule
Emp. Form.:
C14H13BrClFN4O3S
Mol. Mass.:
451.698
SMILES:
CN(CC(=O)Nc1ccc(F)c(Cl)c1)S(=O)(=O)c1cc(Br)cnc1N
Structure:
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