Reaction Details Report a problem with these data
Target
Phospholipase A2, membrane associated
Ligand
BDBM123739
Substrate
n/a
Meas. Tech.
Inhibitory Activity Assay
pH
8±n/a
IC50
2.14e+4± 3.5e+3 nM
Comments
extracted
Citation
 Qiu, S; Chen, F; Liu, Y; Lai, L Discovery of novel secretory phospholipase A2 inhibitors using virtual screen. Chem Biol Drug Des 84:216-22 (2014) [PubMed]  Article 
Target
Name:
Phospholipase A2, membrane associated
Synonyms:
GIIC sPLA2 | Group IIA phospholipase A2 | NPS-PLA2 | Non-Pancreatic Secretory Phospholipase A2 | Non-pancreatic secretory phospholipase A2 (hnps-PLA2) | PA2GA_HUMAN | PLA2B | PLA2G2A | PLA2L | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 group IIA | RASF-A
Type:
Hydrolase
Mol. Mass.:
16101.20
Organism:
Homo sapiens (Human)
Description:
The human nps PLA2 was cloned, and expressed in E. coli. There was a refolding process in the purification.
Residue:
144
Sequence:
MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC
  
Inhibitor
Name:
BDBM123739
Synonyms:
DCSD 001360 (3)
Type:
Small organic molecule
Emp. Form.:
C24H22N2O6
Mol. Mass.:
434.4413
SMILES:
O[NH+]([O-])c1ccc(C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc23)C(O)=O)cc1 |r|
Structure:
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