Reaction Details Report a problem with these data
Target
Phospholipase A2, membrane associated
Ligand
BDBM123743
Substrate
n/a
Meas. Tech.
Inhibitory Activity Assay
pH
8±n/a
IC50
1.22e+4± 1.2e+3 nM
Comments
extracted
Citation
 Qiu, S; Chen, F; Liu, Y; Lai, L Discovery of novel secretory phospholipase A2 inhibitors using virtual screen. Chem Biol Drug Des 84:216-22 (2014) [PubMed]  Article 
Target
Name:
Phospholipase A2, membrane associated
Synonyms:
GIIC sPLA2 | Group IIA phospholipase A2 | NPS-PLA2 | Non-Pancreatic Secretory Phospholipase A2 | Non-pancreatic secretory phospholipase A2 (hnps-PLA2) | PA2GA_HUMAN | PLA2B | PLA2G2A | PLA2L | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 group IIA | RASF-A
Type:
Hydrolase
Mol. Mass.:
16101.20
Organism:
Homo sapiens (Human)
Description:
The human nps PLA2 was cloned, and expressed in E. coli. There was a refolding process in the purification.
Residue:
144
Sequence:
MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC
  
Inhibitor
Name:
BDBM123743
Synonyms:
SPECS AG-690/40108589 (7)
Type:
Small organic molecule
Emp. Form.:
C26H22N4O8
Mol. Mass.:
518.4749
SMILES:
O[NH+]([O-])c1cc(cc(c1)C(=O)Oc1cccc(\C=N\NC(=O)COc2ccc3ccccc3c2)c1)[NH+](O)[O-]
Structure:
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