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Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM125943
Substrate
n/a
Meas. Tech.
Scintillation Proximity Assay
pH
7.5±n/a
IC50
29±n/a nM
Comments
extracted
Citation
 De Lombaert, S; Liu, W; Lo, HY; Nemoto, PA Benzimidazole inhibitors of leukotriene production US Patent  US8772304 Publication Date 7/8/2014 
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Homo sapiens (Human)
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
  
Inhibitor
Name:
BDBM125943
Synonyms:
US8772304, 5
Type:
Small organic molecule
Emp. Form.:
C25H22N10
Mol. Mass.:
462.5092
SMILES:
Cc1ncn(n1)-c1ccc(nc1-c1nc2cc(ccc2n1C1(C)CCC1)-c1cnc(N)nc1)C#N
Structure:
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