Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM130520
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
Temperature
298.15±n/a K
IC50
120±n/a nM
Comments
extracted
Citation
 Straub, A; Lampe, T; Pohlmann, J; Röhrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Substituted oxazolidinones and their use in the field of blood coagulation US Patent  US8822458 Publication Date 9/2/2014 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM130520
Synonyms:
US8822458, 48
Type:
Small organic molecule
Emp. Form.:
C21H22ClFN4O5S
Mol. Mass.:
496.94
SMILES:
OCC(=O)N1CCN(CC1)c1ccc(cc1F)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O |r|
Structure:
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