Reaction Details Report a problem with these data
Target
Endothelial lipase
Ligand
BDBM47168
Substrate
n/a
Meas. Tech.
Inhibition Assay
Temperature
310.15±n/a K
IC50
230±n/a nM
Comments
extracted
Citation
 Masuda, K; Kida, S; Hayashi, K; Katou, M; Yoshikawa, N; Kugimiya, A; Nakajima, M; Tanaka, N Acetic acid amide derivative having inhibitory activity on endothelial lipase US Patent  US8957219 Publication Date 2/17/2015 
Target
Name:
Endothelial lipase
Synonyms:
EDL | EL | Endothelial cell-derived lipase | LIPE_HUMAN | LIPG
Type:
Protein
Mol. Mass.:
56805.62
Organism:
Homo sapiens (Human)
Description:
Q9Y5X9
Residue:
500
Sequence:
MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVVVDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGNFVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHIDIYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDSNRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKNMGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGASQSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWFRKCRDGWRMKNETSPTVELP
  
Inhibitor
Name:
BDBM47168
Synonyms:
US8957219, II-1-1
Type:
n/a
Emp. Form.:
C23H18N2O3S
Mol. Mass.:
402.466
SMILES:
OC(=O)c1cccc(CNC(=O)Cc2nc3ccc(cc3s2)-c2ccccc2)c1
Structure:
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