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Found 230 with Last Name = 'kida' and Initial = 's'
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50128750(7-{2-[(5-Fluoro-benzo[b]thiophene-3-carbonyl)-amin...)
Affinity DataIC50:  0.420nMAssay Description:Prostaglandin D2 receptor antagonist activity, evaluated by inhibition of [3H]-PGD-2 binding to human platelet membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50128768(7-{2-[(5-Hydroxy-benzo[b]thiophene-3-carbonyl)-ami...)
Affinity DataIC50:  0.900nMAssay Description:Concentration required to inhibit the PGD-2 evoked cAMP formation in human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50128768(7-{2-[(5-Hydroxy-benzo[b]thiophene-3-carbonyl)-ami...)
Affinity DataIC50:  1.90nMAssay Description:Prostaglandin D2 receptor antagonist activity, evaluated by inhibition of [3H]-PGD-2 binding to human platelet membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelial lipase(Homo sapiens (Human))
Shionogi

US Patent
LigandPNGBDBM123905(US8754113, I-3-37)
Affinity DataIC50:  2nMT: 2°CAssay Description:After the present compound dissolved in DMSO was added to become 0.5% DMSO to the reaction buffer consisting of 20 mM tris hydrochloric acid (pH7.4),...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50128767(7-{2-[(6-Hydroxy-benzo[b]thiophene-3-carbonyl)-ami...)
Affinity DataIC50:  2.20nMAssay Description:Prostaglandin D2 receptor antagonist activity, evaluated by inhibition of [3H]-PGD-2 binding to human platelet membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50128750(7-{2-[(5-Fluoro-benzo[b]thiophene-3-carbonyl)-amin...)
Affinity DataIC50:  3.20nMAssay Description:Concentration required to inhibit the PGD-2 evoked cAMP formation in human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelial lipase(Homo sapiens (Human))
Shionogi

US Patent
LigandPNGBDBM123908(US8754113, I-3-56)
Affinity DataIC50:  4nMT: 2°CAssay Description:After the present compound dissolved in DMSO was added to become 0.5% DMSO to the reaction buffer consisting of 20 mM tris hydrochloric acid (pH7.4),...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEndothelial lipase(Homo sapiens (Human))
Shionogi

US Patent
LigandPNGBDBM123898(US8754113, I-3-4)
Affinity DataIC50:  4nMT: 2°CAssay Description:After the present compound dissolved in DMSO was added to become 0.5% DMSO to the reaction buffer consisting of 20 mM tris hydrochloric acid (pH7.4),...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50466366(CHEMBL4286190)
Affinity DataIC50:  4.40nMAssay Description:Transrepression of recombinant human GAL4-DBD fused RORgammat LBD expressed in HEK293 cells after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEndothelial lipase(Homo sapiens (Human))
Shionogi

US Patent
LigandPNGBDBM123891(US8754113, I-1-85 | US9169240, 24)
Affinity DataIC50:  5nMT: 2°CAssay Description:After the present compound dissolved in DMSO was added to become 0.5% DMSO to the reaction buffer consisting of 20 mM tris hydrochloric acid (pH7.4),...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50128762(7-{2-[(Benzo[b]thiophene-7-carbonyl)-amino]-6,6-di...)
Affinity DataIC50:  5.60nMAssay Description:Concentration required to inhibit the PGD-2 evoked cAMP formation in human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelial lipase(Homo sapiens (Human))
Shionogi

US Patent
LigandPNGBDBM123890(US8754113, I-1-83)
Affinity DataIC50:  6nMT: 2°CAssay Description:After the present compound dissolved in DMSO was added to become 0.5% DMSO to the reaction buffer consisting of 20 mM tris hydrochloric acid (pH7.4),...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEndothelial lipase(Homo sapiens (Human))
Shionogi

US Patent
LigandPNGBDBM123907(US8754113, I-3-48)
Affinity DataIC50:  8nMT: 2°CAssay Description:After the present compound dissolved in DMSO was added to become 0.5% DMSO to the reaction buffer consisting of 20 mM tris hydrochloric acid (pH7.4),...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEndothelial lipase(Homo sapiens (Human))
Shionogi

US Patent
LigandPNGBDBM123915(US8754113, A-10)
Affinity DataIC50:  8nMT: 2°CAssay Description:After the present compound dissolved in DMSO was added to become 0.5% DMSO to the reaction buffer consisting of 20 mM tris hydrochloric acid (pH7.4),...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50466386(CHEMBL4286603)
Affinity DataIC50:  8.20nMAssay Description:Transrepression of recombinant human GAL4-DBD fused RORgammat LBD expressed in HEK293 cells after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEndothelial lipase(Homo sapiens (Human))
Shionogi

US Patent
LigandPNGBDBM123900(US8754113, I-3-11)
Affinity DataIC50:  9nMT: 2°CAssay Description:After the present compound dissolved in DMSO was added to become 0.5% DMSO to the reaction buffer consisting of 20 mM tris hydrochloric acid (pH7.4),...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEndothelial lipase(Homo sapiens (Human))
Shionogi

US Patent
LigandPNGBDBM123913(US8754113, I-3-163)
Affinity DataIC50:  9nMT: 2°CAssay Description:After the present compound dissolved in DMSO was added to become 0.5% DMSO to the reaction buffer consisting of 20 mM tris hydrochloric acid (pH7.4),...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50466381(CHEMBL4281750)
Affinity DataIC50:  9.80nMAssay Description:Transrepression of recombinant human GAL4-DBD fused RORgammat LBD expressed in HEK293 cells after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50466369(CHEMBL4282801)
Affinity DataIC50:  10nMAssay Description:Transrepression of recombinant human GAL4-DBD fused RORgammat LBD expressed in HEK293 cells after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEndothelial lipase(Homo sapiens (Human))
Shionogi

US Patent
LigandPNGBDBM123914(US8754113, A-9)
Affinity DataIC50:  11nMT: 2°CAssay Description:After the present compound dissolved in DMSO was added to become 0.5% DMSO to the reaction buffer consisting of 20 mM tris hydrochloric acid (pH7.4),...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEndothelial lipase(Homo sapiens (Human))
Shionogi

US Patent
LigandPNGBDBM123893(US8754113, I-2-197)
Affinity DataIC50:  12nMT: 2°CAssay Description:After the present compound dissolved in DMSO was added to become 0.5% DMSO to the reaction buffer consisting of 20 mM tris hydrochloric acid (pH7.4),...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50466375(CHEMBL4287674)
Affinity DataIC50:  13nMAssay Description:Transrepression of RORgammat in anti-CD3/CD28 stimulated human PBMC derived CD4-positive T cells assessed as suppression of T cell differentiation to...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50128757(7-{6,6-Dimethyl-2-[(5-methyl-thiophene-3-carbonyl)...)
Affinity DataIC50:  13nMAssay Description:Prostaglandin D2 receptor antagonist activity, evaluated by inhibition of [3H]-PGD-2 binding to human platelet membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50466374(CHEMBL4279420)
Affinity DataIC50:  14nMAssay Description:Transrepression of recombinant human GAL4-DBD fused RORgammat LBD expressed in HEK293 cells after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50466384(CHEMBL4293415)
Affinity DataIC50:  14nMAssay Description:Transrepression of recombinant human GAL4-DBD fused RORgammat LBD expressed in HEK293 cells after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEndothelial lipase(Homo sapiens (Human))
Shionogi

US Patent
LigandPNGBDBM123906(US8754113, I-3-41)
Affinity DataIC50:  14nMT: 2°CAssay Description:After the present compound dissolved in DMSO was added to become 0.5% DMSO to the reaction buffer consisting of 20 mM tris hydrochloric acid (pH7.4),...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEndothelial lipase(Homo sapiens (Human))
Shionogi

US Patent
LigandPNGBDBM123922(US8754113, A-29)
Affinity DataIC50:  14nMT: 2°CAssay Description:After the present compound dissolved in DMSO was added to become 0.5% DMSO to the reaction buffer consisting of 20 mM tris hydrochloric acid (pH7.4),...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50128738(7-{6,6-Dimethyl-2-[(thiophene-2-carbonyl)-amino]-b...)
Affinity DataIC50:  15nMAssay Description:Concentration required to inhibit the PGD-2 evoked cAMP formation in human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelial lipase(Homo sapiens (Human))
Shionogi

US Patent
LigandPNGBDBM123894(US8754113, I-2-198)
Affinity DataIC50:  15nMT: 2°CAssay Description:After the present compound dissolved in DMSO was added to become 0.5% DMSO to the reaction buffer consisting of 20 mM tris hydrochloric acid (pH7.4),...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50466377(CHEMBL4279772)
Affinity DataIC50:  16nMAssay Description:Transrepression of recombinant human GAL4-DBD fused RORgammat LBD expressed in HEK293 cells after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50128736(7-[2-(2-Furan-3-yl-acetylamino)-6,6-dimethyl-bicyc...)
Affinity DataIC50:  17nMAssay Description:Concentration required to inhibit the PGD-2 evoked cAMP formation in human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50128767(7-{2-[(6-Hydroxy-benzo[b]thiophene-3-carbonyl)-ami...)
Affinity DataIC50:  18nMAssay Description:Concentration required to inhibit the PGD-2 evoked cAMP formation in human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50128744(7-{2-[(Benzo[b]thiophene-2-carbonyl)-amino]-6,6-di...)
Affinity DataIC50:  19nMAssay Description:Prostaglandin D2 receptor antagonist activity, evaluated by inhibition of [3H]-PGD-2 binding to human platelet membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50128751(7-{6,6-Dimethyl-2-[(2-methyl-thiophene-3-carbonyl)...)
Affinity DataIC50:  20nMAssay Description:Concentration required to inhibit the PGD-2 evoked cAMP formation in human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50128749(7-{2-[(Benzo[b]thiophene-3-carbonyl)-amino]-6,6-di...)
Affinity DataIC50:  22nMAssay Description:Concentration required to inhibit the PGD-2 evoked cAMP formation in human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelial lipase(Homo sapiens (Human))
Shionogi

US Patent
LigandPNGBDBM123916(US8754113, A-13)
Affinity DataIC50:  22nMT: 2°CAssay Description:After the present compound dissolved in DMSO was added to become 0.5% DMSO to the reaction buffer consisting of 20 mM tris hydrochloric acid (pH7.4),...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50128757(7-{6,6-Dimethyl-2-[(5-methyl-thiophene-3-carbonyl)...)
Affinity DataIC50:  25nMAssay Description:Concentration required to inhibit the PGD-2 evoked cAMP formation in human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50466367(CHEMBL4290041)
Affinity DataIC50:  25nMAssay Description:Transrepression of recombinant human GAL4-DBD fused RORgammat LBD expressed in HEK293 cells after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50466368(CHEMBL4278291)
Affinity DataIC50:  25nMAssay Description:Transrepression of recombinant human GAL4-DBD fused RORgammat LBD expressed in HEK293 cells after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50128762(7-{2-[(Benzo[b]thiophene-7-carbonyl)-amino]-6,6-di...)
Affinity DataIC50:  26nMAssay Description:Prostaglandin D2 receptor antagonist activity, evaluated by inhibition of [3H]-PGD-2 binding to human platelet membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelial lipase(Homo sapiens (Human))
Shionogi

US Patent
LigandPNGBDBM123912(US8754113, I-3-146)
Affinity DataIC50:  27nMT: 2°CAssay Description:After the present compound dissolved in DMSO was added to become 0.5% DMSO to the reaction buffer consisting of 20 mM tris hydrochloric acid (pH7.4),...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEndothelial lipase(Homo sapiens (Human))
Shionogi

US Patent
LigandPNGBDBM123909(US8754113, I-3-93)
Affinity DataIC50:  28nMT: 2°CAssay Description:After the present compound dissolved in DMSO was added to become 0.5% DMSO to the reaction buffer consisting of 20 mM tris hydrochloric acid (pH7.4),...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50466375(CHEMBL4287674)
Affinity DataIC50:  29nMAssay Description:Transrepression of recombinant human GAL4-DBD fused RORgammat LBD expressed in HEK293 cells after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelial lipase(Homo sapiens (Human))
Shionogi

US Patent
LigandPNGBDBM147471(US8957219, II-2-144)
Affinity DataIC50:  29nMT: 2°CAssay Description:After the present compound dissolved in DMSO was added to become 0.5% DMSO to the reaction buffer consisting of 20 mM tris hydrochloric acid (pH7.4),...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEndothelial lipase(Homo sapiens (Human))
Shionogi

US Patent
LigandPNGBDBM147469(US8957219, II-2-67)
Affinity DataIC50:  29nMT: 2°CAssay Description:After the present compound dissolved in DMSO was added to become 0.5% DMSO to the reaction buffer consisting of 20 mM tris hydrochloric acid (pH7.4),...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50466384(CHEMBL4293415)
Affinity DataIC50: <30nMAssay Description:Displacement of [3H]-Digoxin from recombinant human GST-fused RORgammat LBD after 1 to 4 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50466369(CHEMBL4282801)
Affinity DataIC50: <30nMAssay Description:Displacement of [3H]-Digoxin from recombinant human GST-fused RORgammat LBD after 1 to 4 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50466373(CHEMBL4278285)
Affinity DataIC50: <30nMAssay Description:Displacement of [3H]-Digoxin from recombinant human GST-fused RORgammat LBD after 1 to 4 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50466375(CHEMBL4287674)
Affinity DataIC50: <30nMAssay Description:Displacement of [3H]-Digoxin from recombinant human GST-fused RORgammat LBD after 1 to 4 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50466377(CHEMBL4279772)
Affinity DataIC50: <30nMAssay Description:Displacement of [3H]-Digoxin from recombinant human GST-fused RORgammat LBD after 1 to 4 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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