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Target
Cyclin-dependent kinase 9
Ligand
BDBM167863
Substrate
n/a
Meas. Tech.
LANCE ULight TR-FRET Kinase Assay
IC50
6±n/a nM
Citation
 Gong, J; Tao, Z; Penning, TD; Souers, AJ; Tong, Y; Zhu, G Pyrrolo[2,3-B]pyridine CDK9 kinase inhibitors US Patent  US9073922 Publication Date 7/7/2015 
Target
Name:
Cyclin-dependent kinase 9
Synonyms:
C-2K | CDC2L4 | CDK9 | CDK9_HUMAN | Cell division cycle 2-like protein kinase 4 | Cell division protein kinase 9 | Cyclin-Dependent Kinase 9 (CDK9) | Cyclin-dependent kinase 9 (CDK9) | Serine/threonine-protein kinase PITALRE | TAK | Tat-associated kinase complex catalytic subunit
Type:
Enzyme Subunit
Mol. Mass.:
42789.13
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
372
Sequence:
MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF
  
Inhibitor
Name:
BDBM167863
Synonyms:
US9073922, 360
Type:
Small organic molecule
Emp. Form.:
C26H24F3N5O2
Mol. Mass.:
495.4963
SMILES:
OCC(=O)N1CCC(CC1)c1cc2c(ccnc2[nH]1)-c1nc(NCc2cccc(F)c2)c(F)cc1F
Structure:
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