Reaction Details Report a problem with these data
Target
Glutaminyl-peptide cyclotransferase
Ligand
BDBM179614
Substrate
n/a
Meas. Tech.
Fluorometric Assay
pH
8±n/a
Temperature
303.15±n/a K
Ki
690±n/a nM
IC50
15300±n/a nM
Comments
extracted
Citation
 Heiser, U; Ramsbeck, D; Buchholz, M; Niestroj, AJ Inhibitors of glutaminyl cyclase US Patent  US9126987 Publication Date 9/8/2015 
Target
Name:
Glutaminyl-peptide cyclotransferase
Synonyms:
Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN
Type:
Enzyme
Mol. Mass.:
40877.05
Organism:
Homo sapiens (Human)
Description:
Q16769
Residue:
361
Sequence:
MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL
  
Inhibitor
Name:
BDBM179614
Synonyms:
US9126987, 17
Type:
Small organic molecule
Emp. Form.:
C19H18N4O4S
Mol. Mass.:
398.436
SMILES:
COc1cc(CSc2nnc(o2)-c2ccc3[nH]cnc3c2)cc(OC)c1OC
Structure:
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