Target
Voltage-dependent calcium channel gamma-8 subunit
Ligand
BDBM288220
Substrate
n/a
Meas. Tech.
Calcium Flux Assay
pH
7.4±n/a
IC50
0.126±n/a nM
Comments
extracted
Citation
 Ameriks, MKGyuris, MLaforteza, BNLebold, TPMeyer, STRavula, SSavall, BMShireman, BTWade, WSGerencsér, J Fused bicylic pyridine compounds and their use as AMPA receptor modulators US Patent  US10087185 Publication Date 10/2/2018 
Target
Name:
Voltage-dependent calcium channel gamma-8 subunit
Synonyms:
CACNG6 | CACNG8 | CCG8_HUMAN | Neuronal voltage-gated calcium channel gamma-8 subunit | TARP gamma-8 | Transmembrane AMPAR regulatory protein gamma-8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43326.96
Organism:
Homo sapiens (Human)
Description:
Q8WXS5
Residue:
425
Sequence:
MESLKRWNEERGLWCEKGVQVLLTTVGAFAAFGLMTIAISTDYWLYTRALICNTTNLTAGGDDGTPHRGGGGASEKKDPGGLTHSGLWRICCLEGLKRGVCVKINHFPEDTDYDHDSAEYLLRVVRASSIFPILSAILLLLGGVCVAASRVYKSKRNIILGAGILFVAAGLSNIIGVIVYISANAGEPGPKRDEEKKNHYSYGWSFYFGGLSFILAEVIGVLAVNIYIERSREAHCQSRSDLLKAGGGAGGSGGSGPSAILRLPSYRFRYRRRSRSSSRSSEPSPSRDASPGGPGGPGFASTDISMYTLSRDPSKGSVAAGLAGAGGGGGGAVGAFGGAAGGAGGGGGGGGGAGAERDRGGASGFLTLHNAFPKEAGGGVTVTVTGPPAPPAPAPPAPSAPAPGTLAKEAAASNTNTLNRKTTPV
  
Inhibitor
Name:
BDBM288220
Synonyms:
5-(7-Chloro-1H-indazol-5-yl)-2-cyclopropyl-6-(trifluoromethyl)- | US10087185, Example 38
Type:
Small organic molecule
Emp. Form.:
C17H11ClF3N5
Mol. Mass.:
377.751
SMILES:
FC(F)(F)c1ccc2nc(nn2c1-c1cc(Cl)c2[nH]ncc2c1)C1CC1
Structure:
Search PDB for entries with ligand similarity: