Reaction Details Report a problem with these data
Target
Stearoyl-CoA desaturase
Ligand
BDBM186595
Substrate
n/a
Meas. Tech.
Enzyme Activity Assay
pH
7.5000±n/a
IC50
1±n/a nM
Comments
extracted
Citation
 Lachance, N; Leclerc, J; Li, CS; Moradei, OM Spiro compounds useful as inhibitors of stearoyl-coenzyme A delta-9 desaturase US Patent  US9168248 Publication Date 10/27/2015 
Target
Name:
Stearoyl-CoA desaturase
Synonyms:
Acyl-CoA desaturase | Stearoyl-CoA (SCD1) | SCD_HUMAN | SCD | FADS5 | SCD1 | SCDOS | Stearoyl-CoA desaturase 1
Type:
Enzyme
Mol. Mass.:
41537.27
Organism:
Human
Description:
O00767
Residue:
359
Sequence:
MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYKDKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAHRLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGETFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNYHHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG
  
Inhibitor
Name:
BDBM186595
Synonyms:
US9168248, 22
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
OC(=O)Cn1nnc(n1)-c1cc(no1)N1CCC2(CC1)CCc1c(Br)cccc1O2
Structure:
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