Reaction Details Report a problem with these data
Target
F420-dependent glucose-6-phosphate dehydrogenase
Ligand
BDBM197174
Substrate
n/a
Meas. Tech.
Fluorescence Binding Assay
pH
7±n/a
Kd
1.7e+4± 4e+3 nM
Comments
extracted
Citation
 Oyugi, MA; Bashiri, G; Baker, EN; Johnson-Winters, K Investigating the Reaction Mechanism of F420-Dependent Glucose-6-phosphate Dehydrogenase from Mycobacterium tuberculosis: Kinetic Analysis of the Wild-Type and Mutant Enzymes. Biochemistry 55:5566-5577 (2016) [PubMed]  Article 
Target
Name:
F420-dependent glucose-6-phosphate dehydrogenase
Synonyms:
F420-dependent glucose-6-phosphate dehydrogenase (FGD) | FGD_MYCTO | fgd | fgd1
Type:
Protein
Mol. Mass.:
36981.36
Organism:
Mycobacterium tuberculosis
Description:
P9WNE0
Residue:
336
Sequence:
MAELKLGYKASAEQFAPRELVELAVAAEAHGMDSATVSDHFQPWRHQGGHAPFSLSWMTAVGERTNRLLLGTSVLTPTFRYNPAVIAQAFATMGCLYPNRVFLGVGTGEALNEIATGYEGAWPEFKERFARLRESVGLMRQLWSGDRVDFDGDYYRLKGASIYDVPDGGVPVYIAAGGPAVAKYAGRAGDGFICTSGKGEELYTEKLMPAVREGAAAADRSVDGIDKMIEIKISYDPDPELALNNTRFWAPLSLTAEQKHSIDDPIEMEKAADALPIEQIAKRWIVASDPDEAVEKVGQYVTWGLNHLVFHAPGHDQRRFLELFQSDLAPRLRRLG
  
Inhibitor
Name:
BDBM197174
Synonyms:
Glucose-6-phosphate (G6P)
Type:
Small organic molecule
Emp. Form.:
C6H13O9P
Mol. Mass.:
260.1358
SMILES:
O[C@H](COP(O)(O)=O)[C@H](O)[C@H](O)[C@@H](O)C=O
Structure:
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