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Found 236 with Last Name = 'baker' and Initial = 'en'
TargetAnthranilate phosphoribosyltransferase(Mycobacterium tuberculosis)
University of Auckland

LigandPNGBDBM93073(ACS No 172)
Affinity DataKi:  1.50E+3nMAssay Description:The initial screen was performed in a 96-well plate using the fluoresence-based assay previously described. An enzyme-coupled absorbance-based assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnthranilate phosphoribosyltransferase(Mycobacterium tuberculosis)
University of Auckland

LigandPNGBDBM93074(ACS No 142)
Affinity DataKi:  6.30E+3nMAssay Description:The initial screen was performed in a 96-well plate using the fluoresence-based assay previously described. An enzyme-coupled absorbance-based assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSalicylate synthase(Mycobacterium tuberculosis)
The University of Auckland

LigandPNGBDBM92747(cyclopropyl-AMT)
Affinity DataKi:  1.20E+4nMAssay Description:The thermal stability of MbtI in the absence and presence of inhibitors was measured using a fluorescence-based thermal shift assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnthranilate phosphoribosyltransferase(Mycobacterium tuberculosis)
University of Auckland

LigandPNGBDBM93075(ACS No 145)
Affinity DataKi:  1.50E+4nMAssay Description:The initial screen was performed in a 96-well plate using the fluoresence-based assay previously described. An enzyme-coupled absorbance-based assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnthranilate phosphoribosyltransferase(Mycobacterium tuberculosis)
University of Auckland

LigandPNGBDBM93076(ACS No 174)
Affinity DataKi:  1.80E+4nMAssay Description:The initial screen was performed in a 96-well plate using the fluoresence-based assay previously described. An enzyme-coupled absorbance-based assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnthranilate phosphoribosyltransferase(Mycobacterium tuberculosis)
University of Auckland

LigandPNGBDBM93077(ACS No 179)
Affinity DataKi:  1.90E+4nMAssay Description:The initial screen was performed in a 96-well plate using the fluoresence-based assay previously described. An enzyme-coupled absorbance-based assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnthranilate phosphoribosyltransferase(Mycobacterium tuberculosis)
University of Auckland

LigandPNGBDBM93078(ACS No 126)
Affinity DataKi:  6.00E+4nMAssay Description:The initial screen was performed in a 96-well plate using the fluoresence-based assay previously described. An enzyme-coupled absorbance-based assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnthranilate phosphoribosyltransferase(Mycobacterium tuberculosis)
University of Auckland

LigandPNGBDBM93079(ACS No 165)
Affinity DataKi:  7.90E+4nMAssay Description:The initial screen was performed in a 96-well plate using the fluoresence-based assay previously described. An enzyme-coupled absorbance-based assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnthranilate phosphoribosyltransferase(Mycobacterium tuberculosis)
University of Auckland

LigandPNGBDBM85513(ACS No 10 | CAS_54-21-7 | NSC_5900 | Sodium salicy...)
Affinity DataKi:  1.19E+5nMAssay Description:The initial screen was performed in a 96-well plate using the fluoresence-based assay previously described. An enzyme-coupled absorbance-based assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245691(9-hydroxy-6-(3-(methylamino)propyl)-4-phenylpyrrol...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Chk1 kinase assessed as GST-Cdc25 phosphorylation by Western blot determinationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50232242(4-(2-chlorophenyl)-8-(3-(dimethylamino)propoxy)-9-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245342(4-(2-Chlorophenyl)-9-hydroxy-6-[2-hydroxy-3-(methy...)
Affinity DataIC50:  3nMAssay Description:Inhibition of Chk1 kinase assessed as GST-Cdc25 phosphorylation by Western blot determinationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50374070(CHEMBL271084)
Affinity DataIC50:  4nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245693(4-(2,6-dichlorophenyl)-9-hydroxy-6-(3-(methylamino...)
Affinity DataIC50:  5nMAssay Description:Inhibition of Chk1 kinase assessed as GST-Cdc25 phosphorylation by Western blot determinationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245523(3-(4-(2-chlorophenyl)-9-hydroxy-1,3-dioxo-2,3-dihy...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50374063(CHEMBL270866)
Affinity DataIC50:  7nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245387(3-(4-(2-chlorophenyl)-9-hydroxy-1,3-dioxo-2,3-dihy...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245496(4-(2,6-Dichlorophenyl)-9-hydroxy-6-(3-hydroxypropy...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245457(4-(2,6-Dichlorophenyl)-9-hydroxy-6-(2-hydroxyethyl...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245384(3-(4-(2-chlorophenyl)-9-hydroxy-1,3-dioxo-2,3-dihy...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50232241(4-(2-Chlorophenyl)-9-hydroxy-6-(3-hydroxypropyl)-p...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human Wee1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50232241(4-(2-Chlorophenyl)-9-hydroxy-6-(3-hydroxypropyl)-p...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245425(4-(2-Chlorophenyl)-9-hydroxy-6-[2-(1H-1,2,4-triazo...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50374068(CHEMBL271071)
Affinity DataIC50:  10nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50232232(4-(2-chlorophenyl)-8-(3-(dimethylamino)propoxy)-9-...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human Cdc2 kinase PY15 phosphorylation in HT29 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50192371(4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazol...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245692(4-(2-chlorophenyl)-9-hydroxy-6-(3-(methylamino)pro...)
Affinity DataIC50:  12nMAssay Description:Inhibition of Chk1 kinase assessed as GST-Cdc25 phosphorylation by Western blot determinationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245386(3-(4-(2-chlorophenyl)-9-hydroxy-1,3-dioxo-2,3-dihy...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245458(4-(4-(2-Chlorophenyl)-9-hydroxy-1,3-dioxo-2,3-dihy...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245341(3-(4-(2,6-dichlorophenyl)-9-hydroxy-1,3-dioxo-2,3-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50374067(CHEMBL255427)
Affinity DataIC50:  14nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50374069(CHEMBL255565)
Affinity DataIC50:  14nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245525(3-(4-(2-chlorophenyl)-9-hydroxy-1,3-dioxo-2,3-dihy...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50232227(4-(2-chlorophenyl)-9-hydroxy-6-(2-hydroxyethyl)-8-...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human Wee1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50374060(CHEMBL272267)
Affinity DataIC50:  15nMAssay Description:Inhibition of human Wee1More data for this Ligand-Target Pair
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245459(4-(2-Chlorophenyl)-9-hydroxy-6-[3-(1H-tetrazol-5-y...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50374066(CHEMBL401776)
Affinity DataIC50:  18nMAssay Description:Inhibition of human Wee1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245497(9-Hydroxy-6-(3-hydroxypropyl)-4-(2-methoxyphenyl)-...)
Affinity DataIC50:  18nMAssay Description:Inhibition of Chk1 kinase assessed as GST-Cdc25 phosphorylation by Western blot determinationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245426(4-(2-Chlorophenyl)-9-hydroxy-6-[2-(1H-1,2,4-triazo...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50232235(4-(2-chlorophenyl)-9-hydroxy-6-(2-hydroxyethyl)-8-...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human Wee1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50374064(CHEMBL404335)
Affinity DataIC50:  20nMAssay Description:Inhibition of human Wee1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245731(6-[3-(Dimethylamino)propyl]-9-hydroxy-4-phenylpyrr...)
Affinity DataIC50:  21nMAssay Description:Inhibition of Chk1 kinase assessed as GST-Cdc25 phosphorylation by Western blot determinationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245522(3-(9-Hydroxy-1,3-dioxo-4-phenyl-2,3-dihydropyrrolo...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245423(4-(2-Chlorophenyl)-9-hydroxy-6-[2-(1H-tetrazol-5-y...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50232235(4-(2-chlorophenyl)-9-hydroxy-6-(2-hydroxyethyl)-8-...)
Affinity DataIC50:  22nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50374071(CHEMBL272946)
Affinity DataIC50:  22nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245344(3-(9-hydroxy-1,3-dioxo-4-phenyl-2,3-dihydropyrrolo...)
Affinity DataIC50:  23nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245549(4-(2-Chlorophenyl)-6-(2,3-dihydroxypropyl)-9-hydro...)
Affinity DataIC50:  23nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50245424(4-(2-Chlorophenyl)-9-hydroxy-6-[2-(4H-1,2,4-triazo...)
Affinity DataIC50:  24nMAssay Description:Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50232232(4-(2-chlorophenyl)-8-(3-(dimethylamino)propoxy)-9-...)
Affinity DataIC50:  24nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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