Reaction Details
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F420-dependent glucose-6-phosphate dehydrogenase
Ligand
BDBM197175
Substrate
n/a
Meas. Tech.
Fluorescence Binding Assay
pH
7±n/a
Kd
6.6±0.1 nM
Comments
extracted
Citation
Oyugi, MA; Bashiri, G; Baker, EN; Johnson-Winters, K Investigating the Reaction Mechanism of F420-Dependent Glucose-6-phosphate Dehydrogenase from Mycobacterium tuberculosis: Kinetic Analysis of the Wild-Type and Mutant Enzymes. Biochemistry 55:5566-5577 (2016) [PubMed] Article More Info.:
Target
Name:
F420-dependent glucose-6-phosphate dehydrogenase
Synonyms:
F420-dependent glucose-6-phosphate dehydrogenase (FGD) | FGD_MYCTO | fgd | fgd1
Type:
Protein
Mol. Mass.:
36981.36
Organism:
Mycobacterium tuberculosis
Description:
P9WNE0
Residue:
336
Sequence:
MAELKLGYKASAEQFAPRELVELAVAAEAHGMDSATVSDHFQPWRHQGGHAPFSLSWMTAVGERTNRLLLGTSVLTPTFRYNPAVIAQAFATMGCLYPNRVFLGVGTGEALNEIATGYEGAWPEFKERFARLRESVGLMRQLWSGDRVDFDGDYYRLKGASIYDVPDGGVPVYIAAGGPAVAKYAGRAGDGFICTSGKGEELYTEKLMPAVREGAAAADRSVDGIDKMIEIKISYDPDPELALNNTRFWAPLSLTAEQKHSIDDPIEMEKAADALPIEQIAKRWIVASDPDEAVEKVGQYVTWGLNHLVFHAPGHDQRRFLELFQSDLAPRLRRLG
Inhibitor
Name:
BDBM197175
Synonyms:
F420
Type:
Small organic molecule
Emp. Form.:
C29H36N5O18P
Mol. Mass.:
773.5926
SMILES:
C[C@H](OP(O)(=O)OC[C@@H](O)[C@@H](O)[C@@H](O)Cn1c2cc(=O)ccc2cc2c1[nH]c(=O)[nH]c2=O)C(=O)N[C@@H](CCC(=O)N[C@@H](CCC(O)=O)C(O)=O)C(O)=O
Structure:
