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Target
Endothelial lipase
Ligand
BDBM199211
Substrate
n/a
Meas. Tech.
Endothelial Lipase Assay
pH
7.2±n/a
IC50
959±n/a nM
Comments
extracted
Citation
 Connelly, MA; Greco, M; Ye, H Tricyclic indole derivatives useful endothelial lipase inhibitors US Patent  US9216998 Publication Date 12/22/2015 
Target
Name:
Endothelial lipase
Synonyms:
EDL | EL | Endothelial cell-derived lipase | LIPE_HUMAN | LIPG
Type:
Protein
Mol. Mass.:
56805.62
Organism:
Homo sapiens (Human)
Description:
Q9Y5X9
Residue:
500
Sequence:
MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVVVDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGNFVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHIDIYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDSNRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKNMGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGASQSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWFRKCRDGWRMKNETSPTVELP
  
Inhibitor
Name:
BDBM199211
Synonyms:
US9216998, 16
Type:
Small organic molecule
Emp. Form.:
C24H26F3N3O
Mol. Mass.:
429.4779
SMILES:
CN(C)CC(=O)N1CCn2c(CCc3ccccc3)c(c3cccc(C1)c23)C(F)(F)F
Structure:
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