Reaction Details Report a problem with these data
Target
Potassium channel subfamily K member 2
Ligand
BDBM202558
Substrate
n/a
Meas. Tech.
TREK1 Assay
pH
7.3±n/a
Temperature
295.15±n/a K
IC50
4.7e+3± 2e+2 nM
Comments
extracted
Citation
 Viswanath, AN; Jung, SY; Hwang, EM; Park, KD; Lim, SM; Min, SJ; Cho, YS; Pae, AN Identification of the first in silico-designed TREK1 antagonists that block channel currents dose dependently. Chem Biol Drug Des 88:807-819 (2016) [PubMed]  Article 
Target
Name:
Potassium channel subfamily K member 2
Synonyms:
KCNK2 | KCNK2_HUMAN | Outward rectifying potassium channel protein TREK-1 | TREK | TREK-1 K(+) channel subunit | TREK1 | Twik-RElated Potassium (K+) channel 1 (TREK1) | Two pore domain potassium channel TREK-1 | Two pore potassium channel TPKC1
Type:
Protein
Mol. Mass.:
47099.16
Organism:
Homo sapiens (Human)
Description:
O95069
Residue:
426
Sequence:
MLPSASRERPGYRAGVAAPDLLDPKSAAQNSKPRLSFSTKPTVLASRVESDTTINVMKWKTVSTIFLVVVLYLIIGATVFKALEQPHEISQRTTIVIQKQTFISQHSCVNSTELDELIQQIVAAINAGIIPLGNTSNQISHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVALPAIIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGGSDIEYLDFYKPVVWFWILVGLAYFAAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRATSIKRKLSAELAGNHNQELTPCRRTLSVNHLTSERDVLPPLLKTESIYLNGLTPHCAGEEIAVIENIK
  
Inhibitor
Name:
BDBM202558
Synonyms:
NC30
Type:
Small organic molecule
Emp. Form.:
C24H28F3N3O2
Mol. Mass.:
447.4932
SMILES:
CC(C)Oc1ccc(CN2CCC(O)(Cn3c(cc4cccnc34)C(F)(F)F)CC2)cc1
Structure:
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